Depressive symptoms and academic achievement in UK adolescents: a cross-lagged analysis with genetic covariates.
Depressive symptoms and academic achievement in UK adolescents: a cross-lagged analysis with genetic covariates.
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DOI：
10.1016/j.jad.2021.01.091
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发表时间：
2021-04-01
影响因子：
6.6
通讯作者：
Pearson RM
中科院分区：
文献类型：
--
作者：
López-López JA;Kwong ASF;Washbrook L;Tilling K;Fazel MS;Pearson RM
青少年抑郁症状与学业成绩呈负相关抑郁症状可能影响青少年早期（11-16岁）的后期成就义务教育结束时（16岁）的不良成绩可能影响后期情绪现在可以推导遗传变量，儿童智商和同伴伤害会影响抑郁症状和学业成绩。青少年抑郁症状和学业成绩之间的关系仍然知之甚少。本研究的目的是帮助澄清这种关联的性质和方向。我们使用了13,599名英国青少年的样本（N=3,809名参与者的主样本）。我们拟合交叉滞后面板模型，使用4个自我报告抑郁症状的重复测量值和4个基于11-18岁英国国家记录的学业成就测量值，分别针对男性和女性青少年，并考虑教育程度和抑郁的多基因风险评分（PRS），以及其他儿童和父母的协变量。我们发现总体负相关的证据，男孩（R=-0.21, 95% CI -0.31至-0.11）比女孩（-0.13,-0.31至0.05）更强。较高的抑郁症状与较低的学业成绩有关，直至义务教育结束（16年），当这种关系的方向逆转时，尽管成绩较低的女孩在前一阶段似乎也容易出现抑郁症状。这项研究得出的遗传变量显示与学业成绩有更强的联系，但抑郁症的PRS也显示与女孩的学业成绩负相关。儿童智商与同伴受害也有相关关系。观察设计，测量时间的变化，缺失数据。在为儿童和青少年设计校本方案时，除性别、儿童能力和学校经历外，还应共同考虑抑郁症状和学业成绩。在研究中纳入遗传信息有助于将平均值与时变效应区分开来。
Adolescent depressive symptoms and academic achievement are negatively associated Depressive symptoms might affect later achievement in early adolescence (age 11-16) Poor results at the end of compulsory education (16 years) might affect later mood Genetic variables can now be derived, expect stronger associations with education Child IQ and peer victimization affect both depressive symptoms and academic results The relationship between adolescent depressive symptoms and academic achievement remains poorly understood. The aim of this study was to help clarify the nature and directionality of this association. We used a sample of 13,599 British adolescents (main sample of N=3,809 participants). We fitted cross-lagged panel models using four repeated measures of self-reported depressive symptoms and four measures of academic achievement based on British national records between 11-18 years, separately for male and female adolescents and considering polygenic risk scores (PRS) for educational attainment and depression, alongside other child and parental covariates. We found evidence of an overall negative association that was stronger in boys (R=-0.21, 95% CI -0.31 to -0.11) than in girls (-0.13, -0.31 to 0.05). Higher depressive symptoms were associated with lower academic achievement at a later stage up to the end of compulsory education (16 years), when the direction of the association reversed, although girls with lower achievement also appeared vulnerable to depressive symptoms at previous stages. The genetic variables derived for this study showed stronger associations for academic achievement, but the PRS for depression also showed a negative association with academic achievement in girls. Child intelligence quotient and peer victimization also showed relevant associations. Observational design, variation around measurement times, missing data. Depressive symptoms and academic achievement should be considered jointly when designing school-based programmes for children and adolescents, alongside gender, child ability and school experience. Including genetic information in research can help to disentangle average from time-varying effects.
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基因发现和多基因预测，从基因组全基因组协会的教育程度研究中，有110万个人。
影响因子：
30.8
作者：
Lee JJ;Wedow R;Okbay A;Kong E;Maghzian O;Zacher M;Nguyen-Viet TA;Bowers P;Sidorenko J;Karlsson Linnér R;Fontana MA;Kundu T;Lee C;Li H;Li R;Royer R;Timshel PN;Walters RK;Willoughby EA;Yengo L;23andMe Research Team;COGENT (Cognitive Genomics Consortium);Social Science Genetic Association Consortium;Alver M;Bao Y;Clark DW;Day FR;Furlotte NA;Joshi PK;Kemper KE;Kleinman A;Langenberg C;Mägi R;Trampush JW;Verma SS;Wu Y;Lam M;Zhao JH;Zheng Z;Boardman JD;Campbell H;Freese J;Harris KM;Hayward C;Herd P;Kumari M;Lencz T;Luan J;Malhotra AK;Metspalu A;Milani L;Ong KK;Perry JRB;Porteous DJ;Ritchie MD;Smart MC;Smith BH;Tung JY;Wareham NJ;Wilson JF;Beauchamp JP;Conley DC;Esko T;Lehrer SF;Magnusson PKE;Oskarsson S;Pers TH;Robinson MR;Thom K;Watson C;Chabris CF;Meyer MN;Laibson DI;Yang J;Johannesson M;Koellinger PD;Turley P;Visscher PM;Benjamin DJ;Cesarini D
通讯作者：
Cesarini D
影响因子：
9.2
作者：
Choi, Shing Wan;O'Reilly, Paul F.
通讯作者：
O'Reilly, Paul F.
影响因子：
4.4
作者：
Davies J;Sullivan S;Zammit S
通讯作者：
Zammit S
影响因子：
7
作者：
Hamaker, Ellen L.;Kuiper, Rebecca M.;Grasman, Raoul P. P. P.
通讯作者：
Grasman, Raoul P. P. P.
影响因子：
13.8
作者：
Kwong, Alex S. F.;Lopez-Lopez, Jose A.;Pearson, Rebecca M.
通讯作者：
Pearson, Rebecca M.