Decreased mitochondrial function and increased brain inflammation in bipolar disorder and other neuropsychiatric diseases.
Decreased mitochondrial function and increased brain inflammation in bipolar disorder and other neuropsychiatric diseases.
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双相情感障碍和其他神经精神疾病中线粒体功能下降和脑部炎症增加。
DOI：
10.1097/jcp.0b013e318239c190
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发表时间：
2011
影响因子：
2.9
通讯作者：
P. Conti
中科院分区：
文献类型：
--
作者：
T. Theoharides;B. Zhang;P. Conti
Konradi及其同事最近的一篇综述文章总结了基于双相情感障碍患者大脑整个mRNA库（转录组）分析的基因表达研究结果。转录组与基因组不同，因为它可以受到环境影响的影响。作者得出结论，（a）能量产生基因簇下调，（B）免疫应答基因簇上调，（c）少突胶质细胞功能基因簇大多下调（图1）。他们将这些一般结果与其他作者关于重性抑郁症和精神分裂症的类似可用数据进行了比较，并得出结论，存在显著重叠，因此无法确定双相情感障碍的独特特征。Konradi及其同事回顾了2003年至2009年期间发表的7项使用大脑材料的研究和4项使用双相情感障碍患者外周组织的研究。这些研究并不都是针对相同的集群。在7项使用脑组织的研究中，只有3项研究调查了“能量功能标志物”;其中，2项报告了显著下降，而1项研究报告了增加。7项使用脑组织的研究中只有3项研究了与免疫应答相关的基因表达，所有3项研究均报告了显著增加。只有1项研究调查了少突胶质细胞标志物的表达，发现一些表达降低，但其他表达水平升高。审查了4项使用外周组织的研究;其中，2项研究显示调节能量产生的基因表达降低，只有1项研究调查了与免疫反应相关的基因，并报告了表达显著增加。没有特别的基因被挑出来讨论。然而，作者提出，观察到的转录组变化可能是自身免疫过程的早期阶段，这一过程更引人注目，但与神经系统的变化相似。
Arecent review article by Konradi and coworkers 1 summarized the results of gene expression studies based on analysis of the entire mRNA pool (transcriptome) of brains from patients with bipolar disorder. The transcriptome differs from the genome because it can be shaped by environmental influences. The authors concluded that clusters of genes (a) for energy production were downregulated, (b) for immune responses were up-regulated, and (c) for oligodendrocyte function were mostly down-regulated (Fig. 1). They compared these general outcomes with similar available data from other authors for major depressive disorder and schizophrenia and concluded that there was significant overlap, making it impossible to identify a specific profile unique for bipolar disorder. Konradi and coworkers reviewed 7 published studies between 2003 and 2009 using brain material and 4 studies using peripheral tissue from patients with bipolar disorder. These studies did not all examine the same clusters. Only 3 of the 7 studies using brain tissue investigated ‘‘markers of energy function’’; of these, 2 reported significant decrease, whereas 1 study reported an increase. Only 3 of the 7 studies using brain tissue investigated expression of genes associated with immune response, and all 3 reported significant increase. Only 1 study investigated the expression of oligodendrocyte markers and found decreased expression of some but increased level of others. Four studies using peripheral tissues were reviewed; of these, 2 studies showed decreased expression of genes regulating energy production, and only 1 study investigated genes associated with immune responses and reported significantly increased expression. No particular gene was singled out for discussion. However, the authors proposed that the transcriptome changes observed may be the early stage of an autoimmune process that is more dramatic, but similar to changes in the neuro
影响因子：
2.9
作者：
T. Theoharides;Craig C. Weinkauf;P. Conti
通讯作者：
T. Theoharides;Craig C. Weinkauf;P. Conti