Serological recognition of Toxoplasma gondii cyst antigens.

Serological recognition of Toxoplasma gondii cyst antigens.
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弓形虫包囊抗原的血清学识别。

DOI:
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发表时间:
1996
影响因子:
--
通讯作者:
P. Appleford
P. Appleford
中科院分区:
医学3区
文献类型:
--
作者:
J. Smith;G. McNeil;Y. W. Zhang;S. Dutton;G. Biswas;P. Appleford

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弓形虫感染的特征是急性期,与速殖子的快速增殖有关,随后是慢性期,在此期间缓慢生长的缓殖子阶段在脑和肌肉组织中形成囊肿。尽管组织囊肿通常被称为“休眠”,但有证据表明囊肿内有缓殖子周转(Pavesio 等人,1992 年)和周期性囊肿破裂(Ferguson 等人,1989 年)。从包囊中释放的缓殖子可能会转化为速殖子,导致急性疾病复发,这对于免疫抑制的个体来说可能是致命的(Luft 和 Remington 1992)。疾病的控制依赖于两个阶段的识别和免疫调节,因此了解速殖子和缓殖子的相对抗原结构非常重要。
Infection with Toxoplasma gondii is characterised by an acute phase, associated with the rapid proliferation of tachyzoites, followed by a chronic phase during which the slow-growing bradyzoite stage forms cysts in brain and muscle tissue. Although tissue cysts are often refered to as ‘dormant’, there is evidence of bradyzoite turnover within the cyst (Pavesio et al. 1992) and of periodic cyst rupture (Ferguson et al. 1989). Bradyzoites released from the cyst may convert into tachyzoites causing recrudesence of acute disease which, in immunosuppressed individuals, can be fatal (Luft and Remington 1992). Control of disease relies upon recognition and immunoregulation of both stages and it is therefore important to have an understanding of the comparative antigenic structure of tachyzoites and bradyzoites.
通过单克隆抗体鉴定弓形虫阶段特异性子孢子抗原。
DOI: --
发表时间: 1984
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Kasper,LH;Bradley,MS;Pfefferkorn,ER
通讯作者: Pfefferkorn,ER
弓形虫缓殖子特异性单克隆抗体的鉴定。
DOI: 10.1093/infdis/166.1.213
发表时间: 1992
期刊: The Journal of infectious diseases
影响因子: --
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Weiss,LM;LaPlace,D;Tanowitz,HB;Wittner,M
通讯作者: Wittner,M
使用纯化的弓形虫主膜速殖子抗原 (P30) 接种疫苗会产生意想不到的反应。
DOI: --
发表时间: 1985
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
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Kasper,LH;Currie,KM;Bradley,MS
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急性感染前后获得的人血清识别的弓形虫抗原的分析。
DOI: 10.1093/infdis/154.4.650
发表时间: 1986
期刊: The Journal of infectious diseases
影响因子: --
作者:
Potasman,I;Araujo,FG;Desmonts,G;Remington,JS
通讯作者: Remington,JS