Odour receptors and neurons for DEET and new insect repellents.
Odour receptors and neurons for DEET and new insect repellents.
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作者：
寻找改进的避蚊胺替代品存在重大障碍，因为引起嗅觉排斥的受体是未知的，新的化学物质需要高昂的成本来确定人类使用的安全性。在这里，我们确定DEET敏感神经元在一个坑状结构中的果蝇天线称为球囊。它们表达一种高度保守的受体Ir40a，这些神经元被沉默或Ir40a被敲低的果蝇失去对DEET的回避。我们使用化学信息学筛选了超过400，000种化合物，并确定了超过100种天然化合物作为候选驱虫剂。我们测试了几种，发现大多数激活Ir40a+神经元，是果蝇的驱避剂。这些化合物也是蚊子的强效驱虫剂。候选人含有不溶解塑料的化学物质，价格实惠，闻起来像葡萄一样温和，其中三种被认为对人类消费安全。我们的发现为发现新一代驱虫剂铺平了道路，这些驱虫剂将有助于在全球范围内对抗致命的虫媒疾病。
There are major impediments to finding improved DEET alternatives because the receptors causing olfactory repellency are unknown, and new chemistries require exorbitant costs to determine safety for human use. Here we identify DEET-sensitive neurons in a pit-like structure in the Drosophila antenna called the sacculus. They express a highly conserved receptor Ir40a and flies in which these neurons are silenced or Ir40a is knocked down lose avoidance to DEET. We use cheminformatics to screen >400,000 compounds and identify >100 natural compounds as candidate repellents. We test several and find that most activate Ir40a+ neurons and are repellents for Drosophila. These compounds are strong repellents in mosquitoes as well. The candidates contain chemicals that do not dissolve plastic, are affordable, smell mildly like grapes, with three being considered safe for human consumption. Our findings pave the way to discover new generations of repellents that will help fight deadly insect-borne diseases worldwide.
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影响因子：
5.4
作者：
Corbel V;Stankiewicz M;Pennetier C;Fournier D;Stojan J;Girard E;Dimitrov M;Molgó J;Hougard JM;Lapied B
通讯作者：
Lapied B
影响因子：
48
作者：
Haddad, Rafi;Khan, Rehan;Sobel, Noam
通讯作者：
Sobel, Noam
影响因子：
7.5
作者：
CORTES, C;VAPNIK, V
通讯作者：
VAPNIK, V
影响因子：
64.8
作者：
通讯作者：
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影响因子：
64.5
作者：
Benton R;Vannice KS;Gomez-Diaz C;Vosshall LB
通讯作者：
Vosshall LB