Body Mass Index Trajectories and Biomarkers of Cardiometabolic Risk in Children from Low-Income and Racially and Ethnically Diverse Households.
Body Mass Index Trajectories and Biomarkers of Cardiometabolic Risk in Children from Low-Income and Racially and Ethnically Diverse Households.
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低收入和种族和民族多样化家庭儿童的体重指数轨迹和心脏代谢风险生物标志物。
DOI：
10.1089/chi.2022.0216
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Kunin-Batson,AliciaS
中科院分区：
文献类型：
--
作者：
deBrito,JuniaN;Pereira,MarkA;Kelly,AaronS;Erickson,DarinJ;Sherwood,NancyE;Mason,SusanM;Loth,KatieA;French,SimoneA;Evanoff,NicholasG;Dengel,DonaldR;Kunin-Batson,AliciaS
背景：本研究调查了生活在美国低收入和种族和民族多样化家庭的儿童的BMI轨迹与新出现的心脏代谢风险（CMR）之间的关系。方法：数据来源于NET-Works随机干预试验和NET-Works 2前瞻性随访研究（N= 338）。在6次随访中测量BMI，并在第6次随访时测量心脏代谢风险生物标志物（CMR）。基于组的轨迹建模确定了儿童BMI轨迹。调整后的多变量线性回归评估BMI轨迹与CMR之间的关系。结果：我们确定了两种BMI轨迹：25%的人遵循BMI急剧上升的轨迹，75%的人遵循BMI随时间缓慢下降的轨迹。与中度下降轨迹的儿童相比，升高轨迹的儿童c反应蛋白（CRP）调整后的平均水平更高；3.3;95%可信区间(CI): 1.6 - 5.0),瘦素(63.1;95%可信区间:44.3 - 81.8),甘油三酯(35.4;95%可信区间:22.1 - 48.6),甘油三酸酯/高密度脂蛋白(HDL)比(1.2;95%可信区间:0.8 - 1.6)、糖化血红蛋白(糖化血红蛋白;0.1;95%可信区间:0.03 - 0.2)、空腹血糖(1.8;0.1 - 3.5)和胰岛素(8.8;95%可信区间:6.5 - 11.0),整体CMR得分(0.7;95%可信区间:0.5 - 0.9),并降低脂联素(−1.3;95%可信区间:2.5−−0.1)和高密度脂蛋白(−10.8;95%可信区间:14.3−−7.4)。结论：儿童期早期高BMI的儿童更有可能在整个儿童期保持加速的BMI轨迹，这与青春期前的不良CMR有关。为了促进卫生公平并支持儿童的健康体重和心血管健康轨迹，需要公共卫生努力解决儿童肥胖和CMR方面的持续差异。
Background:This study examined the associations between BMI trajectories and emerging cardiometabolic risk (CMR) in children living in low-income and racially and ethnically diverse households in the United States.Methods:Data were drawn from NET-Works randomized intervention trial and NET-Works 2 prospective follow-up study (N= 338). BMI was measured across 6 follow-up visits and biomarkers of cardiometabolic risk (CMR) at the sixth visit. Group-based trajectory modeling identified child BMI trajectories. Adjusted multivariable linear regressions evaluated the associations between BMI trajectories and CMR.Results:We identified two BMI trajectories: 25% followed a trajectory of steep BMI increase, and 75% followed a moderate decreasing BMI trajectory over time. Relative to children in the moderate decreasing trajectory, children in the increasing trajectory had higher adjusted mean levels of C-reactive protein [CRP; 3.3; 95% confidence interval (CI): 1.6 to 5.0], leptin (63.1; 95% CI: 44.3 to 81.8), triglycerides (35.4; 95% CI: 22.1 to 48.6), triglyceride/high-density lipoprotein (HDL) ratio (1.2; 95% CI: 0.8 to 1.6), hemoglobin A1c (HbA1C; 0.1; 95% CI: 0.03 to 0.2), fasting glucose (1.8; 0.1 to 3.5) and insulin (8.8; 95% CI: 6.5 to 11.0), overall CMR score (0.7; 95% CI: 0.5 to 0.9), and lower adiponectin (−1.3; 95% CI: −2.5 to −0.1) and HDL (−10.8; 95% CI: −14.3 to −7.4).Conclusions:Children with high BMIs early in childhood were more likely to maintain an accelerated BMI trajectory throughout childhood, which was associated with adverse CMR in pre-adolescence. To advance health equity and support children's healthy weight and cardiovascular health trajectories, public health efforts are needed to address persistent disparities in childhood obesity and CMR.
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影响因子：
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作者：
K. Momoi;M. Okamoto;S. Fujii;C. Kim;Y. Miyake;T. Yamano
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DOI：
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1977
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Biochimica et biophysica acta
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DOI：
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1987
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Journal of Steroid Biochemistry
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J. Müller
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DOI：
--
发表时间：
1982
期刊：
Clinical and Experimental Hypertension Part A Theory and Practice
影响因子：
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作者：
S. Ulick;Michael D. Chu
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DOI：
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发表时间：
1972
期刊：
Recent Progress in Hormone Research
影响因子：
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