Interaction of Pattern Recognition Receptors with Mycobacterium Tuberculosis.
Interaction of Pattern Recognition Receptors with Mycobacterium Tuberculosis.
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DOI：
10.1007/s10875-014-0103-7
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发表时间：
2015-01
影响因子：
9.1
通讯作者：
Barnes, Peter J.
中科院分区：
文献类型：
--
作者：
Mortaz, Esmaeil;Adcock, Ian M.;Tabarsi, Payam;Masjedi, Mohammad Reza;Mansouri, Davood;Velayati, Ali Akbar;Casanova, Jean-Laurent;Barnes, Peter J.
结核病（TB）被认为是一个主要的全球性健康问题，每年诊断出1000万新病例。自从结核分枝杆菌（MTB）被鉴定为病原体和识别新的调节感染的信号通路以来，我们对结核免疫学的理解已经变得越来越深入。了解免疫系统细胞识别MTB的机制可能是设计新治疗方法的重要一步，也是改善当前疫苗接种策略有限成功的重要一步。慢性病的一个巨大挑战是了解宿主与病原体相互作用的复杂性、机制和后果。先天免疫应答沿着不同的炎性介质和细胞的参与在宿主防御MTB中起重要作用。几种类型的模式识别受体（PRR）参与MTB的识别，包括与炎性小体激活相关的Toll样受体（TLR）、C型凝集素受体（CLR）和Nod样受体（NLR）。在TLR家族中，TLR 1、TLR 2、TLR 4和TLR 9及其下游信号蛋白在TB发病机制中的免疫应答的起始中起关键作用。炎性体途径与细胞因子如IL-1β和IL-18的协同释放相关，这些细胞因子也在TB的发病机制中发挥作用。了解这些信号通路之间的相互作用将影响新的治疗策略的设计以及疫苗和免疫治疗方案的开发。结核病对PRR信号通路的调控异常将影响疾病的发病机制，有待进一步阐明。在这篇综述中，我们提供了一个更新的PRR信号在M。结核感染，并指出如何更多的知识，这些途径可能会导致新的治疗机会。
Tuberculosis (TB) is considered a major worldwide health problem with 10 million new cases diagnosed each year. Our understanding of TB immunology has become greater and more refined since the identification of Mycobacterium tuberculosis (MTB) as an etiologic agent and the recognition of new signaling pathways modulating infection. Understanding the mechanisms through which the cells of the immune system recognize MTB can be an important step in designing novel therapeutic approaches, as well as improving the limited success of current vaccination strategies. A great challenge in chronic disease is to understand the complexities, mechanisms, and consequences of host interactions with pathogens. Innate immune responses along with the involvement of distinct inflammatory mediators and cells play an important role in the host defense against the MTB. Several classes of pattern recognition receptors (PRRs) are involved in the recognition of MTB including Toll-Like Receptors (TLRs), C-type lectin receptors (CLRs) and Nod-like receptors (NLRs) linked to inflammasome activation. Among the TLR family, TLR1, TLR2, TLR4, and TLR9 and their down-stream signaling proteins play critical roles in the initiation of the immune response in the pathogenesis of TB. The inflammasome pathway is associated with the coordinated release of cytokines such as IL-1β and IL-18 which also play a role in the pathogenesis of TB. Understanding the cross-talk between these signaling pathways will impact on the design of novel therapeutic strategies and in the development of vaccines and immunotherapy regimes. Abnormalities in PRR signaling pathways regulated by TB will affect disease pathogenesis and need to be elucidated. In this review we provide an update on PRR signaling during M. tuberculosis infection and indicate how greater knowledge of these pathways may lead to new therapeutic opportunities.
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DOI：
10.1084/jem.175.4.1111
发表时间：
1992-04-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chan J;Xing Y;Magliozzo RS;Bloom BR
通讯作者：
Bloom BR
影响因子：
--
作者：
Azfar, Shah Farhan;Islam, Najmul
通讯作者：
Islam, Najmul
影响因子：
4.8
作者：
Bulut, Y;Michelsen, KS;Arditi, M
通讯作者：
Arditi, M
影响因子：
3.1
作者：
Branger, J;Knapp, S;van der Poll, T
通讯作者：
van der Poll, T
影响因子：
4.4
作者：
Akira, S;Hemmi, H
通讯作者：
Hemmi, H