PROGRESSIVE POTENTIAL OF MILD CERVICAL ATYPIA: PROSPECTIVE CYTOLOGICAL, COLPOSCOPIC, AND VIROLOGICAL STUDY
PROGRESSIVE POTENTIAL OF MILD CERVICAL ATYPIA: PROSPECTIVE CYTOLOGICAL, COLPOSCOPIC, AND VIROLOGICAL STUDY
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轻度宫颈异型性的进展潜力：前瞻性细胞学、阴道镜和病毒学研究
DOI：
10.1016/s0140-6736(86)92067-2
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
A. Singer
中科院分区：
文献类型：
--
作者：
M. Campion;J. Cuzick;D. Mccance;A. Singer
1983年10月开始对100名有细胞学和阴道镜检查证据的轻度宫颈糜烂的妇女进行前瞻性研究，这些宫颈糜烂与宫颈上皮内瘤变（CIN）I级一致。26%的早期宫颈病变进展为组织学证实的CIN III。仅11例轻度宫颈糜烂自然消退，其中4例CIN复发。通过宫颈细胞学标本的过滤DNA-DNA杂交检测，研究组中人乳头瘤病毒16型（HPV 16）的总体患病率为39%。然而，26例进行性疾病中有22例（85%）HPV 16阳性。HPV 16的检测可能是一种非侵入性的方法，用于识别轻度宫颈糜烂快速进展为CIN III的高风险女性。
A prospective study of 100 women with cytological and colposcopic evidence of mild cervical atypia consistent with cervical intraepithelial neoplasia (CIN) grade I was started in October, 1983. 26% of early preinvasive cervical lesions progressed to histologically proven CIN III. Spontaneous regression of mild cervical atypia occurred in only 11 cases, and in 4 of these CIN recurred. The overall prevalence of human papillomavirus type 16 (HPV 16) in the study group, detected by filter DNA-DNA hybridisation of a cervical cytological specimen, was 39%. However, 22 of the 26 (85%)cases of progressive disease were positive for HPV 16. Detection of HPV 16 may be a non-invasive way of identifying women at high risk of rapid progression of mild cervical atypia to CIN III.
子宫颈人乳头瘤病毒感染：免疫组织化学技术鉴定的 28 例组织学表现。
影响因子：
3.4
作者：
Dyson,JL;Walker,PG;Singer,A
通讯作者：
Singer,A