Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression.
Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression.
复制标题
DOI：
10.3390/ijms23042214
复制
发表时间：
2022-02-17
影响因子：
5.6
通讯作者：
Habuchi T
中科院分区：
文献类型：
--
作者：
Sato H;Narita S;Ishida M;Takahashi Y;Mingguo H;Kashima S;Yamamoto R;Koizumi A;Nara T;Numakura K;Saito M;Yoshioka T;Habuchi T
猪油饮食（LD）是前列腺癌（PCa）发展和进展的危险因素。与鱼油饮食（FOD）相比，用富含饱和和单不饱和脂肪酸（SMFA）的等热量特定脂肪饮食（LD）喂养的两种免疫活性小鼠模型显示出显著增强的PCa进展。高肠道微生物的分歧导致饮食的差异，和丰富的几种细菌物种，如在订单梭菌目和乳酸杆菌目，是显着改变的LD或FOD喂养的小鼠的粪便。肠道中乳酸杆菌目的比例与SMFA诱导的体重增加和PCa进展呈负相关。我们发现在PCa组织中有三种和七种常见的上调和下调基因调节脂质代谢和胆固醇生物合成途径，其中一些与小鼠肠道中乳酸杆菌目的丰度相关。使用NCBI基因表达综合数据库，在小鼠模型中与乳杆菌目和癌症进展相关的鞘氨醇1-磷酸受体2的表达与PCa患者的侵袭性表型和体重增加呈负相关。因此，SMFA可能促进PCa进展与丰富的特定肠道微生物物种和PCa中脂肪生成基因的过表达。改变肠道微生物群和参与饮食诱导的PCa进展的候选基因的治疗方法可能对PCa有吸引力。
Lard diet (LD) is a risk factor for prostate cancer (PCa) development and progression. Two immunocompetent mouse models fed with isocaloric specific fat diets (LD) enriched in saturated and monounsaturated fatty acid (SMFA), showed significanftly enhanced PCa progression with weight gain compared with a fish oil diet (FOD). High gut microbial divergency resulted from difference in diets, and the abundance of several bacterial species, such as in the orders Clostridiales and Lactobacillales, was markedly altered in the feces of LD- or FOD-fed mice. The proportion of the order Lactobacillales in the gut was negatively involved in SMFA-induced body weight gain and PCa progression. We found the modulation of lipid metabolism and cholesterol biosynthesis pathways with three and seven commonly up- and downregulated genes in PCa tissues, and some of them correlated with the abundance of the order Lactobacillales in mouse gut. The expression of sphingosine 1-phosphate receptor 2, which is associated with the order Lactobacillales and cancer progression in mouse models, was inversely associated with aggressive phenotype and weight gain in patients with PCa using the NCBI Gene Expression Omnibus database. Therefore, SMFA may promote PCa progression with the abundance of specific gut microbial species and overexpression of lipogenic genes in PCa. Therapeutics with alteration of gut microbiota and candidate genes involved in diet-induced PCa progression may be attractive in PCa.
登录
查看更多内容
饮食诱导的前列腺癌进展中脂肪酸合酶的改变。
影响因子：
6.2
作者：
Huang, M.;Koizumi, A.;Narita, S.;Inoue, T.;Tsuchiya, N.;Nakanishi, H.;Numakura, K.;Tsuruta, H.;Saito, M.;Satoh, S.;Nanjo, H.;Sasaki, T.;Habuchi, T.
通讯作者：
Habuchi, T.
DOI：
10.1111/febs.12446
发表时间：
2013-12
期刊：
The FEBS journal
影响因子：
--
作者：
Adada M;Canals D;Hannun YA;Obeid LM
通讯作者：
Obeid LM
影响因子：
5.6
作者：
Liotti, Antonietta;Cosimato, Vincenzo;Ulianich, Luca
通讯作者：
Ulianich, Luca
影响因子：
6.6
作者：
Lloyd, Jessica C.;Antonelli, Jodi A.;Freedland, Stephen J.
通讯作者：
Freedland, Stephen J.
肠道菌群失调通过增加 LPCAT1 表达和增强 DNA 修复途径加速前列腺癌进展
影响因子：
4.7
作者：
Liu Y;Yang C;Zhang Z;Jiang H
通讯作者：
Jiang H