Role of "Western diet" in inflammatory autoimmune diseases.
Role of "Western diet" in inflammatory autoimmune diseases.
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DOI：
10.1007/s11882-013-0404-6
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发表时间：
2014-01
影响因子：
5.5
通讯作者：
Kleinewietfeld, Markus
中科院分区：
文献类型：
--
作者：
Manzel, Arndt;Muller, Dominik N.;Hafler, David A.;Erdman, Susan E.;Linker, Ralf A.;Kleinewietfeld, Markus
关键词：
发达社会虽然成功地减少了传染病的负担，但却构成了代谢、心血管和自身免疫性疾病猖獗的环境。生活在西方国家并没有从根本上改变这些疾病出现的遗传基础，但对生活方式和病原体暴露有很大影响。特别是，统称为“西方饮食”的营养模式，包括高脂肪和胆固醇、高蛋白、高糖和过量的盐摄入，以及经常食用加工食品和“快餐”，会促进肥胖、代谢综合征和心血管疾病。这些因子作为自身免疫性疾病的可能促进剂也获得了高度关注。目前正在深入研究潜在的代谢和免疫机制。这篇综述讨论了目前的知识相对于协会的“西方饮食”与自身免疫性，并强调了T细胞的作用，作为中央球员连接饮食的影响，自身免疫性病理。
Developed societies, although having successfully reduced the burden of infectious disease, constitute an environment where metabolic, cardiovascular, and autoimmune diseases thrive. Living in westernized countries has not fundamentally changed the genetic basis on which these diseases emerge, but has strong impact on lifestyle and pathogen exposure. In particular, nutritional patterns collectively termed the “Western diet”, including high-fat and cholesterol, high-protein, high-sugar, and excess salt intake, as well as frequent consumption of processed and ‘fast foods’, promote obesity, metabolic syndrome, and cardiovascular disease. These factors have also gained high interest as possible promoters of autoimmune diseases. Underlying metabolic and immunologic mechanisms are currently being intensively explored. This review discusses the current knowledge relative to the association of “Western diet” with autoimmunity, and highlights the role of T cells as central players linking dietary influences to autoimmune pathology.
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影响因子：
64.8
作者：
Esplugues, Enric;Huber, Samuel;Gagliani, Nicola;Hauser, Anja E.;Town, Terrence;Wan, Yisong Y.;O'Connor, William, Jr.;Rongvaux, Anthony;Van Rooijen, Nico;Haberman, Ann M.;Iwakura, Yoichiro;Kuchroo, Vijay K.;Kolls, Jay K.;Bluestone, Jeffrey A.;Herold, Kevan C.;Flavell, Richard A.
通讯作者：
Flavell, Richard A.
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
5.3
作者：
Chung, Cecilia P.;Oeser, Annette;Stein, C. Michael
通讯作者：
Stein, C. Michael
影响因子：
15.9
作者：
De Rosa, V;Procaccini, C;Matarese, G
通讯作者：
Matarese, G
影响因子：
13
作者：
Ahmed, Mushtaq;Gaffen, Sarah L.
通讯作者：
Gaffen, Sarah L.