Pulling the covers in electronic health records for an association study with self-reported sleep behaviors.
Pulling the covers in electronic health records for an association study with self-reported sleep behaviors.
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DOI：
10.1080/07420528.2018.1508152
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发表时间：
2018-11
影响因子：
2.8
通讯作者：
Hughey JJ
中科院分区：
文献类型：
--
作者：
Rhoades SD;Bastarache L;Denny JC;Hughey JJ
The electronic health record (EHR) contains rich histories of clinical care, but has not traditionally been mined for information related to sleep habits. Here, we performed a retrospective EHR study based on a cohort of 3,652 individuals with self-reported sleep behaviors documented from visits to the sleep clinic. These individuals were obese (mean body mass index 33.6 kg/m2) and had a high prevalence of sleep apnea (60.5%), however we found sleep behaviors largely concordant with prior prospective cohort studies. In our cohort, average wake time was 1 hour later and average sleep duration was 40 minutes longer on weekends than on weekdays (p < 10−12). Sleep duration varied considerably as a function of age and tended to be longer in females and in whites. Additionally, through phenome-wide association analyses, we found an association of long weekend sleep with depression, and an unexpectedly large number of associations of long weekday sleep with mental health and neurological disorders (q < 0.05). We then sought to replicate previously published genetic associations with morning/evening preference on a subset of our cohort with extant genotyping data (n = 555). While those findings did not replicate in our cohort, a polymorphism (rs3754214) in high linkage disequilibrium with a previously published polymorphism near TARS2 was associated with long sleep duration (p < 0.01). Collectively, our results highlight the potential of the EHR for uncovering the correlates of human sleep in real-world populations.
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DOI：
10.3390/s150818950
发表时间：
2015-08-03
期刊：
Sensors (Basel, Switzerland)
影响因子：
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作者：
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通讯作者：
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影响因子：
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通讯作者：
Ruiz JM
DOI：
10.1146/annurev-genom-090314-024956
发表时间：
2016-08-31
影响因子：
8.7
作者：
Denny JC;Bastarache L;Roden DM
通讯作者：
Roden DM
影响因子：
3.7
作者：
Lucassen EA;Zhao X;Rother KI;Mattingly MS;Courville AB;de Jonge L;Csako G;Cizza G;Sleep Extension Study Group
通讯作者：
Sleep Extension Study Group