The biology and clinical significance of acquired genomic copy number aberrations and recurrent gene mutations in chronic lymphocytic leukemia.
The biology and clinical significance of acquired genomic copy number aberrations and recurrent gene mutations in chronic lymphocytic leukemia.
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DOI：
10.1038/onc.2012.411
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发表时间：
2013-06-06
期刊：
影响因子：
8
通讯作者：
Malek, S. N.
中科院分区：
文献类型：
--
作者：
Malek, S. N.
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and remains incurable with conventional chemotherapy treatment approaches. CLL as a disease entity is defined by a relatively parsimonious set of diagnostic criteria and therefore likely constitutes an umbrella term for multiple related illnesses. Of the enduring fundamental biological processes that affect the biology and clinical behavior of CLL, few are as central to the pathogenesis of CLL as recurrent acquired genomic copy number aberrations (aCNA) and recurrent gene mutations. Here, a state-of-the-art overview of the pathological anatomy of the CLL genome is presented, including detailed descriptions of the anatomy of aCNA and gene mutations. Data from SNP array profiling and large-scale sequencing of large CLL cohorts, as well as stimulated karyotyping, are discussed. This review is organized by discussions of the anatomy, underlying pathomechanisms and clinical significance of individual genomic lesions and recurrent gene mutations. Finally, gaps in knowledge regarding the biological and clinical effects of recurrent genomic aberrations or gene mutations on CLL are outlined to provide critical stimuli for future research.
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影响因子：
20.3
作者：
Bullrich, F;Veronese, ML;Croce, CM
通讯作者：
Croce, CM
DOI：
10.1084/jem.20110921
发表时间：
2011-07-04
期刊：
The Journal of experimental medicine
影响因子：
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通讯作者：
Gaidano G
影响因子：
11.4
作者：
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影响因子：
45.3
作者：
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通讯作者：
Stankovic, Tatjana
影响因子：
3.7
作者：
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通讯作者：
Gattei, Valter