Role of sigma receptors in methamphetamine-induced neurotoxicity.
Role of sigma receptors in methamphetamine-induced neurotoxicity.
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DOI：
10.2174/157015911795016930
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发表时间：
2011-03
影响因子：
5.3
通讯作者：
Matsumoto RR
中科院分区：
文献类型：
--
作者：
Kaushal N;Matsumoto RR
甲基苯丙胺（METH）是一种广泛滥用的物质。目前，没有有效的药物治疗来治疗其影响。这就需要确定潜在的新的治疗靶点。METH在生理学相关微摩尔浓度下与σ（σ）受体相互作用。此外，σ受体存在于METH作用的器官如大脑、心脏和肺中。此外，σ受体与各种急性和亚慢性效应有关，如运动刺激、致敏和神经毒性的发展，其中σ受体拮抗剂减弱这些效应。σ受体也可能在METH诱导的精神并发症如抑郁症、精神病、认知和运动缺陷中起作用。引起关注的METH的神经毒性作用可以通过小鼠中的σ受体拮抗剂来预防。从机制上讲，MET诱导的神经毒性涉及多巴胺释放、氧化应激、内质网应激、线粒体死亡级联激活、谷氨酸释放、细胞凋亡、小胶质细胞激活和体温过高等因素。本文综述了文献中的研究，这些研究表明σ受体在许多MET诱导的神经毒性机制中起重要作用。
Methamphetamine (METH) is a widely abused substance world over. Currently, there is no effective pharmacotherapy to treat its effects. This necessitates identification of potential novel therapeutic targets. METH interacts with sigma (σ) receptors at physiologically relevant micromolar concentrations. In addition, σ receptors are present in organs like the brain, heart, and lungs at which METH acts. Additionally, σ receptors have been implicated in various acute and subchronic effects like locomotor stimulation, development of sensitization and neurotoxicity, where σ receptor antagonists attenuate these effects. σ Receptors may also have a role in METH-induced psychiatric complications such as depression, psychosis, cognitive and motor deficits. The neurotoxic effects of METH, which are cause for concern, can be prevented by σ receptor antagonists in mice. Mechanistically, METH-induced neurotoxicity involves factors like dopamine release, oxidative stress, endoplasmic reticulum stress, activation of mitochondrial death cascades, glutamate release, apoptosis, microglial activation, and hyperthermia. This review compiles studies from the literature that suggests an important role for σ receptors in many of the mechanisms of METH-induced neurotoxicity.
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影响因子：
4.4
作者：
Dun, Ying;Thangaraju, Muthusamy;Smith, Sylvia B.
通讯作者：
Smith, Sylvia B.
DOI：
10.1016/s0169-328x(01)00184-x
发表时间：
2001-09-10
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Deng, XL;Wang, Y;Cadet, JL
通讯作者：
Cadet, JL
影响因子：
5.6
作者：
Matsumoto, Rae R.;Shaikh, Jamaluddin;Coop, Andrew
通讯作者：
Coop, Andrew
影响因子：
4
作者：
Cassano, Giuseppe;Gasparre, Giuseppe;Colabufo, Nicola Antonio
通讯作者：
Colabufo, Nicola Antonio
影响因子：
2.9
作者：
DECOSTER, MA;KLETTE, KL;TORTELLA, FC
通讯作者：
TORTELLA, FC