Fluoride and organic weak acids as respiration inhibitors for oral streptococci in acidified environments.
Fluoride and organic weak acids as respiration inhibitors for oral streptococci in acidified environments.
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氟化物和有机弱酸作为酸化环境中口腔链球菌的呼吸抑制剂。
DOI：
10.1046/j.0902-0055.2001.00103.x
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发表时间：
2002
影响因子：
--
通讯作者：
Marquis,RE
中科院分区：
文献类型：
--
作者：
Phan,T-N;Nguyen,PTM;Abranches,J;Marquis,RE
Oxygen metabolism (respiration) ofStreptococcus mutansGS‐5 involving NADH oxidases, mainly of the H2O‐producing type, was found to be acid sensitive, as was NADH oxidase activity of cell extracts. Respiration of intact cells in acidified media was also highly sensitive to fluoride, with a 50% inhibitory concentration of about 0.02 mM at pH 4. In contrast, NADH oxidases in cell extracts were fluoride insensitive. Fluoride inhibition of respiration of intact cells was related to weak‐acid effects leading to enhanced proton permeability of cells, cytoplasmic acidification and resultant acid inhibition of NADH oxidases and glycolysis. Organic weak acids, such as indomethacin and benzoate, were also effective inhibitors. H2O2production by intact cells ofStreptococcus sanguisNCTC 10904, a peroxide producer, was similarly inhibited by fluoride or organic weak acids in acidified media. Thus, weak acids act as respiratory inhibitors for oral streptococci indirectly by acidifying the cytoplasm rather than acting as direct inhibitors of NADH oxidases.
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(S)-酮洛芬和氟化物对大鼠龋齿的影响。
影响因子：
3.8
作者：
W. Bowen;S. Pearson;T. P. Jerussi
通讯作者：
T. P. Jerussi
变形链球菌 H2O2 形成 NADH 氧化酶是一种烷基氢过氧化物还原酶蛋白。
影响因子：
7.4
作者：
Poole,LB;Higuchi,M;Shimada,M;Calzi,ML;Kamio,Y
通讯作者：
Kamio,Y
影响因子：
2.8
作者：
BELLI, WA;BUCKLEY, DH;MARQUIS, RE
通讯作者：
MARQUIS, RE
影响因子：
3.1
作者：
CARLSSON, J;KUJALA, U;EDLUND, MBK
通讯作者：
EDLUND, MBK
影响因子：
--
作者：
HIGUCHI, M
通讯作者：
HIGUCHI, M