Quantitative Parameters from OCT Angiography in Patients with Diabetic Retinopathy and in Those with Only Peripheral Retinopathy Compared with Control Participants.
Quantitative Parameters from OCT Angiography in Patients with Diabetic Retinopathy and in Those with Only Peripheral Retinopathy Compared with Control Participants.
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DOI：
10.1016/j.xops.2021.100030
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发表时间：
2021-06
影响因子：
--
通讯作者：
Chakravarthy, Usha
中科院分区：
文献类型：
--
作者：
Hogg, Ruth E.;Wright, David M.;Dolz-Marco, Rosa;Gray, Calum;Waheed, Nadia;Teussink, Michel M.;Naskas, Timos;Perais, Jennifer;Das, Radha;Quinn, Nicola;Bontzos, George;Nicolaou, Constantinos;Annam, Kaushik;Young, Ian S.;Kee, Frank;McGuiness, Bernadette;Mc Kay, Gareth;MacGillivray, Tom;Peto, Tunde;Chakravarthy, Usha
关键词：
描述一系列定量OCT血管造影（OCTA）指标在糖尿病视网膜病变（DR）早期阶段的差异，提供可靠的效果评估以及敏感性和特异性。基于人群抽样的横断面研究。来自296人的441只眼睛：328只对照眼睛（无糖尿病和无DR）， 55只糖尿病和无DR， 58只早期非增生性DR。多模态视网膜成像包括彩色眼底摄影，彩色Optomap超宽视场成像和带有OCTA模块的光谱域OCT （Spectralis OCT2; Heidelberg Engineering GmbH）。所有图像都根据DR特征的存在和严重程度进行分级。基于质量手动评估OCTA图像是否包含。通过早期治疗糖尿病视网膜病变研究（ETDRS）网格、中央凹无血管区（FAZ）面积、FAZ最小和最大直径、周长和圆度，评估去除三维投影伪影后的二元OCTA指标，包括神经纤维层血管丛、浅血管丛（SVC）和深血管丛（DVC）。糖尿病与视网膜外周DR状态及有无DR。与对照组相比，患有糖尿病和明显DR的受试者血管密度的下降幅度往往是患有糖尿病但没有DR的受试者的两倍。在尚未发生DR的患者中发现了血管减少的空间异质性的证据，而那些有明显DR的患者在整个ETDRS网格中都有显著的减少。DM对FAZ周长和圆度的影响最为显著，DR组的多光谱分形维数较对照降低。与DM患者相比，周围DR患者仅在DVC和SVC的上外区、颞内区和颞外区血管密度降低。受试者工作特征曲线下面积在0.48 ~ 0.73之间。在使用商用设备进行最小图像后处理之前，DM患者的OCTA指标存在显著差异。虽然诊断性能较差，但这些指标可能有助于衡量临床试验中随时间的变化。
To describe the differences in a range of quantitative OCT angiography (OCTA) metrics across early stages of diabetic retinopathy (DR), providing robust effect estimates as well as sensitivity and specificity. Cross-sectional study with population-based sampling. Four hundred forty-one eyes from 296 individuals: 328 control eyes (no diabetes mellitus [DM] and no DR), 55 eyes with DM and no DR, and 58 eyes with early nonproliferative DR. Multimodal retinal imaging included color fundus photography, color Optomap ultra-widefield imaging, and spectral-domain OCT (Spectralis OCT2; Heidelberg Engineering GmbH) with the OCTA module. All images were graded for the presence and severity of DR features. OCTA images were assessed manually for inclusion based on quality. Binary OCTA metrics were assessed after 3-dimensional projection artifact removal including from the nerve fiber layer vascular plexus, superficial vascular plexus (SVC), and deep vascular plexus (DVC) by Early Treatment Diabetic Retinopathy Study (ETDRS) grid, foveal avascular zone (FAZ) area, FAZ minimum and maximum diameter, perimeter length, and circularity. Diabetes mellitus and DR status and presence or absence of DR in the retinal periphery. The reduction in vessel densities in participants with DM and manifest DR compared with control participants tended to be twice that of those with DM, but no DR, compared with control participants. Some evidence of spatial heterogeneity in vessel reductions was found in those yet to develop DR, whereas those with manifest DR had significant reductions across the ETDRS grid. The FAZ perimeter and circularity were impacted most significantly by DM, and those with DR showed decreased multispectral fractal dimensions compared with control participants. Eyes with peripheral DR had reduced vessel density compared with those with DM and no DR only in the superior outer, temporal inner, and temporal outer regions in the DVC and SVC. The area under the receiver operating characteristic curve ranged between 0.48 and 0.73. Significant differences in OCTA metrics can be found in those with DM before manifest DR using commercially available equipment with minimal image postprocessing. Although diagnostic performance was poor, these metrics may be useful for measuring change over time in clinical trials.
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影响因子：
3.9
作者：
Palochak, Cherilyn Mae A.;Lee, Hee Eun;Fawzi, Amani A.
通讯作者：
Fawzi, Amani A.
影响因子：
--
作者：
KUWABARA, T;COGAN, DG
通讯作者：
COGAN, DG
影响因子：
4.2
作者：
Greig, Eugenia Custo;Brigell, Mitchell;Waheed, Nadia K.
通讯作者：
Waheed, Nadia K.
影响因子：
1
作者：
Leng, Yunxia;Tam, Emily K.;Tsui, Irena
通讯作者：
Tsui, Irena
影响因子：
4.4
作者：
Kim AY;Chu Z;Shahidzadeh A;Wang RK;Puliafito CA;Kashani AH
通讯作者：
Kashani AH