Comparison of Propagation Models and Forward Calculation Methods on Cellular, Tissue and Organ Scale Atrial Electrophysiology
Comparison of Propagation Models and Forward Calculation Methods on Cellular, Tissue and Organ Scale Atrial Electrophysiology
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细胞、组织和器官尺度心房电生理学的传播模型和正演计算方法的比较
DOI：
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发表时间：
2022
影响因子：
4.6
通讯作者：
A. Loewe
中科院分区：
文献类型：
--
作者：
C. Nagel;C. B. Espinosa;K. Gillette;M. Gsell;Jorge S'anchez;G. Plank;O. Dössel;A. Loewe
目的：bidomain模型和有限元方法是一个既定的标准，以数学描述心脏电生理学，但都是次优的选择，快速和大规模的模拟，由于计算成本高。我们调查在何种程度上简化的方法传播模型（单域，反应Eikonal和Eikonal）和正向计算（边界元和无限体积导体）提供显着加速，但生理上准确的模拟结果在心房电生理学。研究方法：我们比较了健康和纤维浸润心房模型上窦性心律模拟的动作电位持续时间、局部激动时间（LAT）和心电图（ECG）。结果：所有简化模型解均得到了与bidomain结果一致的LAT和P波。仅对于Eikonal模型，预先计算的动作电位模板在时间上移动，以获得跨膜电压，复极行为显着偏离bidomain结果。与有限元法相比，用边界元法计算的ECG的特征在于相关系数$>$0.9。无限体积导体法导致较低的相关系数，主要是由于系统高估了心前区导联中的P波振幅。结论：我们的研究结果表明，Eikonal模型产生准确的LAT和结合边界元法精确的心电图相比，显着更昂贵的全bidomain模拟。然而，为了准确表示心房复极动力学，必须在简化模型中考虑弥散项。重要性：心房LAT和ECG的模拟可以通过诉诸Eikonal和边界元方法以高精度显著加速到临床可行的时间帧。
Objective: The bidomain model and the finite element method are an established standard to mathematically describe cardiac electrophysiology, but are both suboptimal choices for fast and large-scale simulations due to high computational costs. We investigate to what extent simplified approaches for propagation models (monodomain, reaction-Eikonal and Eikonal) and forward calculation (boundary element and infinite volume conductor) deliver markedly accelerated, yet physiologically accurate simulation results in atrial electrophysiology. Methods: We compared action potential durations, local activation times (LATs), and electrocardiograms (ECGs) for sinus rhythm simulations on healthy and fibrotically infiltrated atrial models. Results: All simplified model solutions yielded LATs and P waves in accurate accordance with the bidomain results. Only for the Eikonal model with pre-computed action potential templates shifted in time to derive transmembrane voltages, repolarization behavior notably deviated from the bidomain results. ECGs calculated with the boundary element method were characterized by correlation coefficients $>$0.9 compared to the finite element method. The infinite volume conductor method led to lower correlation coefficients caused predominantly by systematic overestimations of P wave amplitudes in the precordial leads. Conclusion: Our results demonstrate that the Eikonal model yields accurate LATs and combined with the boundary element method precise ECGs compared to markedly more expensive full bidomain simulations. However, for an accurate representation of atrial repolarization dynamics, diffusion terms must be accounted for in simplified models. Significance: Simulations of atrial LATs and ECGs can be notably accelerated to clinically feasible time frames at high accuracy by resorting to the Eikonal and boundary element methods.
心脏电生理学中空间和时间离散化影响的数值研究
DOI：
10.1002/cnm.3443
发表时间：
2021
影响因子：
2.1
作者：
Woodworth L.A;Cansiz;Kaliske M.
通讯作者：
Kaliske M.
心脏的功能成像和建模
DOI：
10.1007/978-3-319-20309-6_48
发表时间：
2015
期刊：
--
影响因子：
--
作者：
Kharche S
通讯作者：
Kharche S