Changes in the amplitude of low-frequency fluctuations in specific frequency bands in major depressive disorder after electroconvulsive therapy.
Changes in the amplitude of low-frequency fluctuations in specific frequency bands in major depressive disorder after electroconvulsive therapy.
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重度抑郁症电休克治疗后特定频段低频波动幅度的变化
DOI：
10.5498/wjp.v12.i5.708
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发表时间：
2022-05-19
影响因子：
3.1
通讯作者：
Luo, Qing-Hua
中科院分区：
文献类型：
--
作者：
Li, Xin-Ke;Qiu, Hai-Tang;Hu, Jia;Luo, Qing-Hua
关键词：
重度抑郁症（MDD）往往具有高发病率和高自杀风险。电休克疗法（ECT）是目前治疗重度抑郁症相对有效的治疗方法。然而，ECT的疗效机制仍不清楚。探讨MDD患者ECT术后特定频段低频波动幅度的变化。本研究招募了 22 名 MDD 患者和 15 名健康对照 (HC)。 MDD 患者接受了 8 次双颞叶 ECT 治疗。采用静息态功能磁共振成像检查MDD患者和健康人的局部小脑血流。 MDD 患者接受两次扫描（第一次 ECT 之前和第八次 ECT 后）以获取数据。然后，计算低频波动 (ALFF) 的幅度，以表征不同频段（典型频率、慢速 5 和慢速 4 频段）的内在神经振荡。与ECT前（ECT前）相比，我们发现MDD患者在第八次ECT后（ECT后）在右侧额中回、后扣带回、右侧缘上回、左侧额上回和左侧角回的典型带中具有较高的ALFF。右颞上回有较低的 ALFF。与ECT前相比，ECT后患者右侧边缘叶、小脑后叶、右侧眶额中回和额叶的slow-5带的ALFF显着升高，而左侧亚叶区、右侧角回和右侧额叶的slow-5带的ALFF较低。相比之下，在额叶、额上回、顶叶、右顶下小叶和左角回中观察到slow-4带中的ALFF显着较高。我们的结果表明，ECT 治疗前和治疗后 MDD 患者的异常 ALFF 可能与特定频段相关。
Major depressive disorder (MDD) tends to have a high incidence and high suicide risk. Electroconvulsive therapy (ECT) is currently a relatively effective treatment for MDD. However, the mechanism of efficacy of ECT is still unclear. To investigate the changes in the amplitude of low-frequency fluctuations in specific frequency bands in patients with MDD after ECT. Twenty-two MDD patients and fifteen healthy controls (HCs) were recruited to this study. MDD patients received 8 ECT sessions with bitemporal placement. Resting-state functional magnetic resonance imaging was adopted to examine regional cerebellar blood flow in both the MDD patients and HCs. The MDD patients were scanned twice (before the first ECT session and after the eighth ECT session) to acquire data. Then, the amplitude of low-frequency fluctuations (ALFF) was computed to characterize the intrinsic neural oscillations in different bands (typical frequency, slow-5, and slow-4 bands). Compared to before ECT (pre-ECT), we found that MDD patients after the eighth ECT (post-ECT) session had a higher ALFF in the typical band in the right middle frontal gyrus, posterior cingulate, right supramarginal gyrus, left superior frontal gyrus, and left angular gyrus. There was a lower ALFF in the right superior temporal gyrus. Compared to pre-ECT values, the ALFF in the slow-5 band was significantly increased in the right limbic lobe, cerebellum posterior lobe, right middle orbitofrontal gyrus, and frontal lobe in post-ECT patients, whereas the ALFF in the slow-5 band in the left sublobar region, right angular gyrus, and right frontal lobe was lower. In contrast, significantly higher ALFF in the slow-4 band was observed in the frontal lobe, superior frontal gyrus, parietal lobe, right inferior parietal lobule, and left angular gyrus. Our results suggest that the abnormal ALFF in pre- and post-ECT MDD patients may be associated with specific frequency bands.
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