Nicotinamide Riboside Alleviates Corneal and Somatic Hypersensitivity Induced by Paclitaxel in Male Rats.
Nicotinamide Riboside Alleviates Corneal and Somatic Hypersensitivity Induced by Paclitaxel in Male Rats.
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DOI：
10.1167/iovs.63.1.38
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发表时间：
2022-01-03
影响因子：
4.4
通讯作者：
Hammond DL
中科院分区：
文献类型：
--
作者：
Hamity MV;Kolker SJ;Hegarty DM;Blum C;Langmack L;Aicher SA;Hammond DL
接受化疗的患者可能会出现眼部不适和干眼样症状;后者可能是神经性的。本研究评估了紫杉醇处理的雄性大鼠的角膜和躯体超敏反应，以及烟酰胺核苷（NR）是否缓解了该反应。在不存在和存在500 mg/kg/os NR持续给药的情况下，在紫杉醇给药前后评估角膜对触觉和化学刺激的敏感性、基础泪液产生以及后爪对触觉和冷刺激的敏感性。角膜神经密度和后爪表皮内神经纤维（IENF）密度也进行了检查。紫杉醇治疗的大鼠角膜过敏触觉刺激，增强敏感性辣椒素，但不是高渗盐水，并增加基础泪液分泌。抗β-微管蛋白或降钙素基因相关肽（CGRP）显示的角膜神经密度不受影响。紫杉醇诱导触觉和冷超敏反应的后爪和损失nonpeptidergic后爪IENF可视化与抗蛋白基因产物（PGP）9.5和CGRP。NR逆转角膜的触觉超敏反应，而不抑制泪液产生或化学敏感性;它不改变角膜传入密度。NR还逆转了后爪的触觉和冷超敏反应，而没有逆转后爪IENF的损失。这些结果表明，紫杉醇可能是一个很好的翻译模型化疗引起的眼部不适，NR可能是有用的，其救济。NR的能力，以减轻躯体触觉过敏的感觉神经支配的变化独立表明，终端乔木退化的逆转是不重要的NR的行动。
Patients receiving chemotherapy may experience ocular discomfort and dry eye–like symptoms; the latter may be neuropathic in nature. This study assessed corneal and somatic hypersensitivity in male rats treated with paclitaxel and whether it was relieved by nicotinamide riboside (NR). Corneal sensitivity to tactile and chemical stimulation, basal tear production, and sensitivity of the hindpaw to tactile and cool stimuli were assessed before and after paclitaxel in the absence and presence of sustained treatment with 500 mg/kg per os NR. Corneal nerve density and hindpaw intraepidermal nerve fiber (IENF) density were also examined. Paclitaxel-treated rats developed corneal hypersensitivity to tactile stimuli, enhanced sensitivity to capsaicin but not hyperosmolar saline, and increased basal tear production. Corneal nerve density visualized with anti–β-tubulin or calcitonin gene-related peptide (CGRP) was unaffected. Paclitaxel induced tactile and cool hypersensitivity of the hindpaw and a loss of nonpeptidergic hindpaw IENFs visualized with anti-protein gene product (PGP) 9.5 and CGRP. NR reversed tactile hypersensitivity of the cornea without suppressing tear production or chemosensitivity; it did not alter corneal afferent density. NR also reversed tactile and cool hypersensitivity of the hindpaw without reversing the loss of hindpaw IENFs. These findings suggest that paclitaxel may be a good translational model for chemotherapy-induced ocular discomfort and that NR may be useful for its relief. The ability of NR to relieve somatic tactile hypersensitivity independent of changes in sensory nerve innervation suggests that reversal of terminal arbor degeneration is not critical to the actions of NR.
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影响因子：
3
作者：
Cho, Jooyoung;Bell, Nicholas;Albuquerque, Romulo J. C.
通讯作者：
Albuquerque, Romulo J. C.
DOI：
10.1111/j.1460-9568.2011.07652.x
发表时间：
2011-05
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Bennett GJ;Liu GK;Xiao WH;Jin HW;Siau C
通讯作者：
Siau C
影响因子：
7.4
作者：
Hamity MV;White SR;Blum C;Gibson-Corley KN;Hammond DL
通讯作者：
Hammond DL
影响因子：
3.4
作者：
Ferrari, Giulio;Nalassamy, Nambi;Oaklander, Anne Louise
通讯作者：
Oaklander, Anne Louise
影响因子：
6.4
作者：
Chiang, Jeremy Chung Bo;Goldstein, David;Markoulli, Maria
通讯作者：
Markoulli, Maria