Increased transmission of Mycobacterium tuberculosis Beijing genotype strains associated with resistance to streptomycin: a population-based study.
Increased transmission of Mycobacterium tuberculosis Beijing genotype strains associated with resistance to streptomycin: a population-based study.
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北京结核分枝杆菌的传播增加了与链霉素抗性相关的基因型菌株：一项基于人群的研究。
DOI：
10.1371/journal.pone.0042323
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Cobelens FG
中科院分区：
文献类型：
--
作者：
Buu TN;van Soolingen D;Huyen MN;Lan NT;Quy HT;Tiemersma EW;Kremer K;Borgdorff MW;Cobelens FG
研究表明，结核分枝杆菌北京基因型是一种新兴病原体，通常与耐药性相关。这表明，与其他耐药菌株相比，北京耐药菌株具有相对较高的传播适应性。我们在一项基于人群的研究中研究了北京基因型与抗结核药物耐药性之间的相对传播适应性，该研究对越南农村地区前瞻性招募和研究的涂片阳性结核病患者进行了为期四年的研究。基于三种 DNA 分型方法，通过病例聚类分析传播适应性。在纳入的 2531 名患者中，2207 名患者 (87%) 符合分析资格，其中 936 名患者 (42%) 属于 DNA 指纹簇。聚类率因基因型而异，北京基因型为292/786（37%），东非印度人（EAI）基因型为527/802（67%），其他基因型为117/619（19%）。与北京基因型相比，聚类与 EAI 相关（调整优势比 (ORadj) 3.4：95% CI 2.8–4.4）。当 EAI 基因型（ORadj 0.6，95% CI 0.4-0.9）时，链霉素耐药菌株感染的患者比链霉素敏感菌株感染的患者更少出现聚集，而北京基因型菌株的这种模式则相反（ORadj 1.3，95% CI 1.0-1.8，p 差异 0.002）。仅当存在链霉素耐药性时，北京与耐多药结核病之间的强相关性（ORadj 7.2；95% CI 4.2-12.3）才存在。北京基因型菌株的总体传播力低于EAI菌株，但在基因型内进行比较时，北京菌株在链霉素抗性时表现出传播适应性增加，而EAI菌株则相反。该人群中耐多药结核病与北京基因型之间的关联强烈依赖于对链霉素的耐药性。链霉素耐药性可能为北京菌株提供了优于其他基因型的适应性优势，并导致感染北京菌株的患者容易产生多重耐药性。
Studies have shown that the Mycobacterium tuberculosis Beijing genotype is an emerging pathogen that is frequently associated with drug resistance. This suggests that drug resistant Beijing strains have a relatively high transmission fitness compared to other drug-resistant strains. We studied the relative transmission fitness of the Beijing genotype in relation to anti-tuberculosis drug resistance in a population-based study of smear-positive tuberculosis patients prospectively recruited and studied over a 4-year period in rural Vietnam. Transmission fitness was analyzed by clustering of cases on basis of three DNA typing methods. Of 2531 included patients, 2207 (87%) were eligible for analysis of whom 936 (42%) were in a DNA fingerprint cluster. The clustering rate varied by genotype with 292/786 (37%) for the Beijing genotype, 527/802 (67%) for the East-African Indian (EAI) genotype, and 117/619 (19%) for other genotypes. Clustering was associated with the EAI compared to the Beijing genotype (adjusted odds ratio (ORadj) 3.4: 95% CI 2.8–4.4). Patients infected with streptomycin-resistant strains were less frequently clustered than patients infected with streptomycin-susceptible strains when these were of the EAI genotype (ORadj 0.6, 95% CI 0.4–0.9), while this pattern was reversed for strains of the Beijing genotype (ORadj 1.3, 95% CI 1.0–1.8, p for difference 0.002). The strong association between Beijing and MDR-TB (ORadj 7.2; 95% CI 4.2–12.3) existed only if streptomycin resistance was present. Beijing genotype strains showed less overall transmissibility than EAI strains, but when comparisons were made within genotypes, Beijing strains showed increased transmission fitness when streptomycin-resistant, while the reverse was observed for EAI strains. The association between MDR-TB and Beijing genotype in this population was strongly dependent on resistance to streptomycin. Streptomycin resistance may provide Beijing strains with a fitness advantage over other genotypes and predispose to multidrug resistance in patients infected with Beijing strains.
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影响因子：
3.7
作者：
Dou HY;Tseng FC;Lin CW;Chang JR;Sun JR;Tsai WS;Lee SY;Su IJ;Lu JJ
通讯作者：
Lu JJ
影响因子：
11.8
作者：
Glynn JR;Crampin AC;Traore H;Yates MD;Mwaungulu FD;Ngwira BM;Chaguluka SD;Mwafulirwa DT;Floyd S;Murphy C;Drobniewski FA;Fine PE
通讯作者：
Fine PE
DOI：
10.1016/j.trstmh.2009.03.013
发表时间：
2009-12-01
影响因子：
2.2
作者：
Houben, Rein M. G. J.;Crampin, Amelia C.;Glynn, Judith R.
通讯作者：
Glynn, Judith R.
影响因子：
3.7
作者：
Huyen MN;Tiemersma EW;Lan NT;Cobelens FG;Dung NH;Sy DN;Buu TN;Kremer K;Hang PT;Caws M;O'Brien R;van Soolingen D
通讯作者：
van Soolingen D
影响因子：
11.8
作者：
Cowley, Donna;Govender, Dhirendra;Nicol, Mark P.
通讯作者：
Nicol, Mark P.