Giant proteins in a giant cell: Molecular basis of ultrafast Ca(2+)-dependent cell contraction.
Giant proteins in a giant cell: Molecular basis of ultrafast Ca(2+)-dependent cell contraction.
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DOI：
10.1126/sciadv.add6550
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发表时间：
2023-02-22
期刊：
影响因子：
13.6
通讯作者：
中科院分区：
文献类型：
--
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The giant single-celled eukaryote, Spirostomum, exhibits one of the fastest movements in the biological world. This ultrafast contraction is dependent on Ca2+ rather than ATP and therefore differs to the actin-myosin system in muscle. We obtained the high-quality genome of Spirostomum minus from which we identified the key molecular components of its contractile apparatus, including two major Ca2+ binding proteins (Spasmin 1 and 2) and two giant proteins (GSBP1 and GSBP2), which act as the backbone and allow for the binding of hundreds of spasmins. The evidence suggests that the GSBP-spasmin protein complex is the functional unit of the mesh-like contractile fibrillar system, which, coupled with various other subcellular structures, provides the mechanism for repetitive ultrafast cell contraction and extension. These findings improve our understanding of the Ca2+-dependent ultrafast movement and provide a blueprint for future biomimicry, design, and construction of this kind of micromachine. Two giant proteins serve as the core components of ultrafast ATP-independent contractile fibrillar system.
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影响因子：
64.8
作者：
CARONI, P;CARAFOLI, E
通讯作者：
CARAFOLI, E
DOI：
10.1111/j.1550-7408.1964.tb01754.x
发表时间：
1964-01-01
期刊：
JOURNAL OF PROTOZOOLOGY
影响因子：
--
作者：
FINLEY, HE;DANIEL, WA;BROWN, CA
通讯作者：
BROWN, CA
DOI：
10.1007/978-1-4939-8793-1_18
发表时间：
2019-01-01
期刊：
ELECTROPHORETIC SEPARATION OF PROTEINS
影响因子：
--
作者：
Greaser, Marion L.;Warren, Chad M.
通讯作者：
Warren, Chad M.
影响因子：
4
作者：
Gogendeau, Delphine;Klotz, Catherine;Beisson, Janine
通讯作者：
Beisson, Janine
影响因子：
12.3
作者：
Haas, Brian J.;Salzberg, Steven L.;Zhu, Wei;Pertea, Mihaela;Allen, Jonathan E.;Orvis, Joshua;White, Owen;Buell, C. Robin;Wortman, Jennifer R.
通讯作者：
Wortman, Jennifer R.