Targeting Viral Surface Proteins through Structure-Based Design.
Targeting Viral Surface Proteins through Structure-Based Design.
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DOI：
10.3390/v13071320
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发表时间：
2021-07-08
期刊：
影响因子：
--
通讯作者：
Strauch EM
中科院分区：
文献类型：
--
作者：
Narkhede YB;Gonzalez KJ;Strauch EM
The emergence of novel viral infections of zoonotic origin and mutations of existing human pathogenic viruses represent a serious concern for public health. It warrants the establishment of better interventions and protective therapies to combat the virus and prevent its spread. Surface glycoproteins catalyzing the fusion of viral particles and host cells have proven to be an excellent target for antivirals as well as vaccines. This review focuses on recent advances for computational structure-based design of antivirals and vaccines targeting viral fusion machinery to control seasonal and emerging respiratory viruses.
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DOI：
10.1056/nejmoa2029849
发表时间：
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期刊：
The New England journal of medicine
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