Hyperacute autonomic and cortical function recovery following cardiac arrest resuscitation in a rodent model.
Hyperacute autonomic and cortical function recovery following cardiac arrest resuscitation in a rodent model.
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DOI：
10.1002/acn3.51907
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发表时间：
2023-12
影响因子：
5.3
通讯作者：
Geocadin, Romergryko G.
中科院分区：
文献类型：
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作者：
Guo, Yu;Gharibani, Payam;Agarwal, Prachi;Cho, Sung-Min;Thakor, Nitish V.;Geocadin, Romergryko G.
神经系统和心血管系统之间存在复杂的相互作用，但关于心脏骤停复苏时脑-心电生理反应的数据很少。我们的目的是研究复苏后超急性期自主神经和皮质功能的动态变化。10只大鼠从7分钟心脏骤停中复苏，作为自主神经反应指标，心率（HR）及其变异性（HRV）被测量。通过连续心电图监测心率，而通过频谱分析评估HRV，其中低频/高频（LF/HF）功率的比例表明交感/副交感神经活动之间的平衡。通过连续脑电图和定量分析评估皮质反应。在复苏后的第一个小时内，每隔5分钟对参数进行量化。在复苏后4小时，通过神经功能缺损评分（NDS，范围0-80，越高=预后越好）评估神经功能预后。复苏后15-30分钟内HR显著增加（p < 0.01 vs.15 min），并与较高的NDS相关（rs = 0.56, p < 0.01）。LF/HF比值15 ~ 20 min与NDS呈正相关（rs = 0.75, p < 0.05）。复苏后15-30分钟伽马波段功率激增（分别与0-15分钟相比p < 0.05），此期间伽马波段分数与NDS相关（rs≥0.70,p < 0.05）。复苏后15-30分钟内HR和γ波段功率增加之间存在显著相关性（rs≥0.83,p < 0.01），复苏后15-20分钟内γ波段分数和LF/HF比值之间存在显著相关性（rs = 0.85, p < 0.01）。自主神经和皮质功能的超急性恢复与良好的功能预后相关。虽然这一观察结果需要进一步验证，但它为复苏后早期更好的自主神经监测提供了一个转化机会，以开发新的干预措施。
There is a complex interaction between nervous and cardiovascular systems, but sparse data exist on brain–heart electrophysiological responses to cardiac arrest resuscitation. Our aim was to investigate dynamic changes in autonomic and cortical function during hyperacute stage post‐resuscitation. Ten rats were resuscitated from 7‐min cardiac arrest, as indicators of autonomic response, heart rate (HR), and its variability (HRV) were measured. HR was monitored through continuous electrocardiography, while HRV was assessed via spectral analysis, whereby the ratio of low−/high‐frequency (LF/HF) power indicates the balance between sympathetic/parasympathetic activities. Cortical response was evaluated by continuous electroencephalography and quantitative analysis. Parameters were quantified at 5‐min intervals over the first‐hour post‐resuscitation. Neurological outcome was assessed by Neurological Deficit Score (NDS, range 0–80, higher = better outcomes) at 4‐h post‐resuscitation. A significant increase in HR was noted over 15–30 min post‐resuscitation (p < 0.01 vs.15‐min, respectively) and correlated with higher NDS (rs = 0.56, p < 0.01). LF/HF ratio over 15–20 min was positively correlated with NDS (rs = 0.75, p < 0.05). Gamma band power surged over 15–30 min post‐resuscitation (p < 0.05 vs. 0–15 min, respectively), and gamma band fraction during this period was associated with NDS (rs ≥0.70, p < 0.05, respectively). Significant correlations were identified between increased HR and gamma band power during 15–30 min (rs ≥0.83, p < 0.01, respectively) and between gamma band fraction and LF/HF ratio over 15–20 min post‐resuscitation (rs = 0.85, p < 0.01). Hyperacute recovery of autonomic and cortical function is associated with favorable functional outcomes. While this observation needs further validation, it presents a translational opportunity for better autonomic and neurologic monitoring during early periods post‐resuscitation to develop novel interventions.
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影响因子：
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作者：
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