Influenza vaccine responses in older adults.
Influenza vaccine responses in older adults.
复制标题
DOI：
10.1016/j.arr.2010.10.008
复制
发表时间：
2011-07
影响因子：
13.1
通讯作者：
McElhaney, Janet E.
中科院分区：
文献类型：
--
作者：
McElhaney, Janet E.
免疫衰老对公共卫生造成的最严重后果是，老年人对流感的易感性增加，目前的裂解病毒流感疫苗失去效力，而这些疫苗在年轻人群中非常有效。在65岁以上的人群中，流感感染与包括肺炎、心脏病发作和中风在内的复杂疾病的高发病率相关。先天性和适应性免疫功能的变化不仅会降低对疫苗接种的反应和对流感的保护，而且对新疫苗的开发提出了重大挑战。在老年人中，疫苗接种的目标更现实地针对提供针对疾病的临床保护，而不是消除免疫力。临床保护的相关性可能无法使用标准技术（如抗体滴度）来预测疫苗效力。此外，对疫苗接种的抗体应答作为保护的相关物可能无法检测到细胞免疫的重要变化和增强的疫苗介导的对老年人流感疾病的保护。本文将讨论流感在老年人中的影响，提高疫苗效力的免疫学靶点，以及更有效地翻译新型疫苗接种策略以提高老年人对流感的保护所需的临床保护的替代相关性。
The most profound consequences of immune senescence with respect to public health are the increased susceptibility to influenza and loss of efficacy of the current split-virus influenza vaccines in older adults, which are otherwise very effective in younger populations. Influenza infection is associated with high rates of complicated illness including pneumonia, heart attacks and strokes in the 65+ population. Changes in both innate and adaptive immune function not only converge in the reduced response to vaccination and protection against influenza, but present significant challenges to new vaccine development. In older adults, the goal of vaccination is more realistically targeted to providing clinical protection against disease rather sterilizing immunity. Correlates of clinical protection may not be measured using standard techniques such as antibody titres to predict vaccine efficacy. Further, antibody responses to vaccination as a correlate of protection may fail to detect important changes in cellular immunity and enhanced vaccine-mediated protection against influenza illness in older people. This article will discuss the impact of influenza in older adults, immunologic targets for improved efficacy of the vaccines, and alternative correlates of clinical protection against influenza that are needed for more effective translation of novel vaccination strategies to improved protection against influenza in older adults.
登录
查看更多内容
影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
20.3
作者：
Dixit, Vishwa D.;Yang, Hyunwon;Taub, Dennis D.
通讯作者：
Taub, Dennis D.
影响因子：
3.7
作者：
Boon, ACM;Fringuelli, E;Osterhaus, ADME
通讯作者：
Osterhaus, ADME
影响因子：
5.5
作者：
de Bruijn, Iris;Meyer, Ingo;Palache, Bram
通讯作者：
Palache, Bram
影响因子：
6.4
作者：
de Bruijn, IA;Remarque, EJ;Knook, DL
通讯作者：
Knook, DL