Developmentally specified characterization of the irritability spectrum at early school age: Implications for pragmatic mental health screening.

Developmentally specified characterization of the irritability spectrum at early school age: Implications for pragmatic mental health screening.
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DOI:
10.1002/mpr.1985
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发表时间:
2023-11
影响因子:
3.1
通讯作者:
Roy, Amy K.
Roy, Amy K.
中科院分区:
医学3区
文献类型:
--
作者:
Hirsch, Emily;Alam, Tasmia;Kirk, Nathan;Bevans, Katherine B.;Briggs-Gowan, Margaret;Wakschlag, Lauren S.;Wiggins, Jillian L.;Roy, Amy K.

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对于早期学龄儿童来说,需要确定临床显著易怒的特定发育措施,以有意义地捕捉这种精神病理学的跨诊断危险因素。因此,目前的研究模拟了正常:异常应激谱,并为这一人群生成了临床优化的筛查工具。用项目反应理论(IRT)对儿童(n=474;6.0-8.9岁)的多维评定量表-脾气损失量表(MAP-TL-Young)的青年版进行建模。既包括儿童早期版本的横切核心易怒项目,也包括新的特定于发展的项目。唯一与损伤相关的项目被识别并用于得出简短的、临床优化的过敏性筛查。然后利用纵向数据来测试这种经过临床优化的筛查器在青春期前(n=348;8.0-12.9岁)的预测效用。大多数儿童经常表现出易怒,但日常发生的情况很少见。在IRT分析中最严重的10个项目中,有9个来自为MAP-TL青年版添加的特定于发育的项目。对于临床优化的应激性筛查者,确定了两项与并发损害相关的项目(“变得容易受挫”和“表现易怒”)。临床优化的MAP-TL-Young筛选器对并发的DSM 5刺激性相关诊断显示出良好的灵敏度(69%)和特异度(84%)。在早期学龄(ESA)筛查中得分较高的年轻人在青春期前患上与易怒相关的精神病理学的几率要高出7倍以上。MAP-TL-Young表征了ESA易怒的发育谱,临床优化的筛查器在预测精神病理风险方面表现出了希望。临床应用的严格测试是关键的下一步。
Developmentally specified measures that identify clinically salient irritability are needed for early school‐age youth to meaningfully capture this transdiagnostic risk factor for psychopathology. Thus, the current study modeled the normal:abnormal irritability spectrum and generated a clinically optimized screening tool for this population. The irritability spectrum was modeled via the youth version of the Multidimensional Assessment Profile Scales—Temper Loss Scale (MAPS‐TL‐Youth) in children (n = 474; 6.0–8.9 years) using item response theory (IRT). Both cross‐cutting core irritability items from the early childhood version and new developmentally specific items were included. Items uniquely associated with impairment were identified and used to derive a brief, clinically optimized irritability screener. Longitudinal data were then utilized to test the predictive utility of this clinically optimized screener in preadolescence (n = 348; 8.0–12.9 years). Most children exhibit irritability regularly, but daily occurrence was rare. Of the top 10 most severe items from the IRT analyses, 9 were from the developmentally specific items added for the MAPS‐TL Youth version. Two items associated with concurrent impairment were identified for the clinically optimized irritability screener (“Become frustrated easily” and “Act irritable”). The MAPS‐TL‐Youth clinically optimized screener demonstrated good sensitivity (69%) and specificity (84%) in relation to concurrent DSM 5 irritability‐related diagnoses. Youth with elevated scores on the screener at early school age (ESA) had more than 7x greater odds of irritability‐related psychopathology at pre‐adolescence. The MAPS‐TL‐Youth characterized the developmental spectrum of irritability at ESA and a clinically optimized screener showed promise at predicting psychopathology risk. Rigorous testing of clinical applications is a critical next step.
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