Significant reduction in the duration of transient voltage responses of a plasmonic nanopore sensor by use of a Chebyshev filter
Significant reduction in the duration of transient voltage responses of a plasmonic nanopore sensor by use of a Chebyshev filter
复制标题
使用切比雪夫滤波器显着减少等离子体纳米孔传感器的瞬态电压响应持续时间
DOI：
10.1117/12.2650798
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Alexandrakis, George
中科院分区：
文献类型：
--
作者：
Asadzadeh, Homayoun;Turpin, Scott;Renkes, Scott;Kim, Min Jun;Alexandrakis, George
我们提出了切比雪夫滤波器电路的等离子体纳米孔传感器的瞬态电流响应在突然的电压反转的影响。这些反转类似于用于具有电纳米孔的单分子捕获-再捕获的反转。我们的等离子体纳米孔传感器允许在纳米颗粒的光学捕获及其随后通过位于传感器中心的纳米孔的移位期间同时记录光学和电学数据。这项工作旨在解决的技术挑战是传感器对突然电压反转的瞬态响应很强（接近饱和电流尖峰），也很慢（在ms范围内返回基线）。在该不应期期间，分析物的移位可能被传感器的瞬态响应混淆。在这里，我们测试使用切比雪夫滤波器作为一种可能的手段，显着降低传感器的瞬态响应电压反转，使分析物的易位不被掩盖的瞬态响应。同时，我们还测试了在测试分析物（20 nm SiO2纳米颗粒）的捕获期间检测到的电特征也不会被相同的过滤器无意地去除。这项工作是朝着开发一种方法的第一步，该方法能够通过我们的等离子体纳米孔传感器快速捕获分析物。
We present the effects of a Chebyshev filter circuit on the transient electrical current responses of a plasmonic nanopore sensor during abrupt voltage reversals. Those reversals are similar to ones used for single molecule capture-recapture with electrical nanopores. Our plasmonic nanopore sensor allows simultaneous recording of optical and electrical data during optical trapping of nanoparticles and their subsequent translocation through the nanopore located at the sensor’s center. The technical challenge this work aims to resolve is that the sensor’s transient response to abrupt voltage reversals is strong (near-saturation current spikes) and is also slow (return to baseline in the ms range). During this refractory period an analyte’s translocation may be obfuscated by the sensor’s transient response. Here we test the use of a Chebyshev filter as a possible means of significantly reducing the sensor’s transient response to voltage reversals so that analyte translocations are not masked by those transient responses. At the same time, we also test that electrical signatures detected during trapping of a test analyte (20 nm SiO2 nanoparticles) are not unintentionally also removed by the same filter. This work is as a first step towards developing a methodology for enabling rapid analyte recapture by our plasmonic nanopore sensor.
影响因子：
2.9
作者：
Lee, Jung Soo;Saharia, Jugal;Kim, Min Jun
通讯作者：
Kim, Min Jun