Bioinspired heme, heme/nonheme diiron, heme/copper, and inorganic NOx chemistry: *NO((g)) oxidation, peroxynitrite-metal chemistry, and *NO((g)) reductive coupling.
Bioinspired heme, heme/nonheme diiron, heme/copper, and inorganic NOx chemistry: *NO((g)) oxidation, peroxynitrite-metal chemistry, and *NO((g)) reductive coupling.
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DOI：
10.1021/ic100033y
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发表时间：
2010-07-19
影响因子：
4.6
通讯作者：
Karlin KD
中科院分区：
文献类型：
--
作者：
Schopfer MP;Wang J;Karlin KD
本次论坛审查的重点突出了我们自己的实验室和其他实验室在生物化学和生物启发无机化学领域的工作，涉及一氧化氮（一氧化氮，·NO（g））及其生物作用和反应。后者的重点是（i）通过一氧化氮双加氧酶（NOD's）将·NO（g）氧化为硝酸盐，以及（ii）两个·NO（g）分子还原偶联生成N2 O（g）。在前一种情况下，NOD的描述和突出可能的过氧亚硝酸盐血红素中间体和后果，这是由最近的工作与肌红蛋白和合成血红素模型系统NOD行动的讨论。综述了近年来铜与NO（g）和O2（g）形成过氧亚硝酸根的络合物化学。·NO（g）的生物还原偶联的覆盖范围涉及具有血红素/非血红素二铁活性位点的细菌一氧化氮还原酶（NOR），以及可以介导相同化学的血红素/Cu氧化酶（如细胞色素c氧化酶）。最近设计的蛋白质和合成模型化合物（血红素/非血红素二铁或血红素/铜）作为功能模拟物进行了详细讨论。我们还强调了化学文献中的例子，不一定涉及生物相关的金属离子，这些例子描述了·NO（g）氧化为硝酸盐（或亚硝酸盐）和可能的过氧亚硝酸盐中间体，或·NO（g）还原偶联产生一氧化二氮。
The focus of this Forum review highlights work from our own laboratories and those of others in the area of biochemical and biologically inspired inorganic chemistry dealing with nitric oxide (nitrogen monoxide, ·NO(g)) and its biological roles and reactions. The latter focus is on (i) oxidation of ·NO(g) to nitrate by nitric oxide dioxygenases (NOD’s), and (ii) reductive coupling of two molecules of ·NO(g) to give N2O(g). In the former case, NOD’s are described and the highlighting of possible peroxynitrite-heme intermediates and consequences of this are given by discussion of recent works with myoglobin and a synthetic heme model system for NOD action. Summaries of recent copper complex chemistries with ·NO(g) and O2(g) leading to peroxynitrite species are given. The coverage of biological reductive coupling of ·NO(g) deals with bacterial nitric oxide reductases (NOR’s) with heme/non-heme diiron active sites, and on heme/Cu oxidases such as cytochrome c oxidase which can mediate the same chemistry. Recent designed protein and synthetic model compound (heme/non-heme diiron or heme/copper) as functional mimics are discussed in some detail. We also highlight examples from the chemical literature, not necessarily involving biologically relevant metal ions, which describe the oxidation of ·NO(g) to nitrate (or nitrite) and possible peroxynitrite intermediates, or reductive coupling of ·NO(g) to give nitrous oxide.
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影响因子：
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