Hyperbaric oxygen therapy: solution for difficult to heal acute wounds? Systematic review.
Hyperbaric oxygen therapy: solution for difficult to heal acute wounds? Systematic review.
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DOI：
10.1007/s00268-010-0923-4
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发表时间：
2011-03
影响因子：
2.6
通讯作者：
Vermeulen, Hester
中科院分区：
文献类型：
--
作者：
Eskes, Anne M.;Ubbink, Dirk T.;Lubbers, Maarten J.;Lucas, Cees;Vermeulen, Hester
高压氧疗法（HBOT）用于治疗各种类型的伤口。然而，HBOT 对急性伤口可能产生的有益和有害影响尚不清楚。我们进行了系统评价，以评估 HBOT 与其他干预措施相比对急性伤口患者伤口愈合和不良反应的有效性。为了检测所有可用的随机对照试验 (RCT)，我们检索了截至 2010 年 3 月的五个相关数据库。试验选择、质量评估、数据提取和数据合成由两位作者独立进行。我们纳入了 5 项试验，总共 360 名患者。这些试验存在一些方法学缺陷，包括不同类型的伤口并侧重于不同的结果参数，从而无法进行荟萃分析。一项法国试验（n = 36 名患者）报告称，与假 HBOT 相比，使用 HBOT 治愈的挤压伤明显更多[相对风险 (RR) 1.70，95% 置信区间 (CI) 1.11–2.61]。此外，HBOT 所需的额外外科手术显着减少（RR 1.60，95% CI 1.03–2.50），并且组织坏死显着减少（RR 1.70，95% CI 1.11–2.61）。在两项美国试验 (n = 141) 中的一项中，HBOT 烧伤伤口的愈合速度明显快于常规烧伤护理 (P < 0.005)。英国的一项试验（n = 48）将 HBOT 与常规护理进行了比较。 HBOT 导致裂皮移植中健康移植面积的百分比显着升高（RR 3.50，95% CI 1.35-9.11）。在一项中国试验（n = 145）中，HBOT 并未显着改善肢体皮肤缺损患者的皮瓣存活率。 HBOT，如果容易获得，似乎可以有效治疗急性、难以愈合的伤口。
Hyperbaric oxygen therapy (HBOT) is used to treat various wound types. However, the possible beneficial and harmful effects of HBOT for acute wounds are unclear. We undertook a systematic review to evaluate the effectiveness of HBOT compared to other interventions on wound healing and adverse effects in patients with acute wounds. To detect all available randomized controlled trials (RCTs) we searched five relevant databases up to March 2010. Trial selection, quality assessment, data extraction, and data synthesis were conducted by two of the authors independently. We included five trials, totaling 360 patients. These trials, with some methodologic flaws, included different kinds of wound and focused on different outcome parameters, which prohibited meta-analysis. A French trial (n = 36 patients) reported that significantly more crush wounds healed with HBOT than with sham HBOT [relative risk (RR) 1.70, 95% confidence interval (CI) 1.11–2.61]. Moreover, there were significantly fewer additional surgical procedures required with HBOT (RR 1.60, 95% CI 1.03–2.50), and there was significantly less tissue necrosis (RR 1.70, 95% CI 1.11–2.61). In one of two American trials (n = 141) burn wounds healed significantly quicker with HBOT (P < 0.005) than with routine burn care. A British trial (n = 48) compared HBOT with usual care. HBOT resulted in a significantly higher percentage of healthy graft area in split skin grafts (RR 3.50, 95% CI 1.35–9.11). In a Chinese trial (n = 145) HBOT did not significantly improve flap survival in patients with limb skin defects. HBOT, if readily available, appears effective for the management of acute, difficult to heal wounds.
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影响因子：
3.1
作者：
Lee, Charles K.;Hansen, Scott L.
通讯作者：
Hansen, Scott L.
DOI：
10.1097/00005373-199608000-00023
发表时间：
1996-08-01
影响因子：
--
作者：
Bouachour, G;Cronier, P;Alquier, P
通讯作者：
Alquier, P
影响因子：
16.2
作者：
Löndahl M;Katzman P;Nilsson A;Hammarlund C
通讯作者：
Hammarlund C
影响因子：
--
作者：
Wang, CC;Schwaitzberg, S;Lau, J
通讯作者：
Lau, J