Composition, structure and function of the corneal stroma.
Composition, structure and function of the corneal stroma.
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DOI：
10.1016/j.exer.2020.108137
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发表时间：
2020-09
影响因子：
3.4
通讯作者：
Birk DE
中科院分区：
文献类型：
--
作者：
Espana EM;Birk DE
身体中没有其他组织比角膜基质更依赖于细胞外基质（ECM）的组成和组织以实现正常结构和功能。在发育过程中发生并在成人中维持基质功能所需的胶原原纤维、层粘连和角膜细胞的精确排列和定向取决于多种ECM组分的调节相互作用，这些ECM组分有助于获得角膜的独特性质：透明度、形状、机械强度和无血管性。本文综述了不同的ECM成分的贡献，它们的结构，调节和功能，在调节角膜基质的性质。原纤维形成胶原（I、III、V）、具有间断三螺旋的原纤维相关胶原（XII和XIV）、网络形成胶原（IV、VI和VIII）以及在基质中表达的小的富含亮氨酸的蛋白聚糖（SLRP）：核心蛋白聚糖、双糖链蛋白聚糖、光蛋白聚糖、角质蛋白聚糖和纤调蛋白是本手稿中综述的一些ECM组分。这些ECM组分的表达存在空间和时间差异，以及它们之间的相互作用有助于基质功能。独特的区域内的基质，如鲍曼层和德斯密层进行了讨论。定义角膜基质组成和结构的复杂性以及与功能的关系是一项艰巨的任务。我们的知识正在扩大，我们希望这次审查提供了一个全面的概述，目前的知识，差距的定义，并建议未来的研究方向。
No other tissue in the body depends more on the composition and organization of the extracellular matrix (ECM) for normal structure and function than the corneal stroma. The precise arrangement and orientation of collagen fibrils, lamellae and keratocytes that occurs during development and is needed in adults to maintain stromal function is dependent on the regulated interaction of multiple ECM components that contribute to attain the unique properties of the cornea: transparency, shape, mechanical strength, and avascularity. This review summarizes the contribution of different ECM components, their structure, regulation and function in modulating the properties of the corneal stroma. Fibril forming collagens (I, III, V), fibril associated collagens with interrupted triple helices (XII and XIV), network forming collagens (IV, VI and VIII) as well as small leucine-rich proteoglycans (SLRP) expressed in the stroma: decorin, biglycan, lumican, keratocan, and fibromodulin are some of the ECM components reviewed in this manuscript. There are spatial and temporal differences in the expression of these ECM components, as well as interactions among them that contribute to stromal function. Unique regions within the stroma like Bowman’s layer and Descemet’s layer are discussed. To define the complexity of corneal stroma composition and structure as well as the relationship to function is a daunting task. Our knowledge is expanding, and we expect that this review provides a comprehensive overview of current knowledge, definition of gaps and suggests future research directions.
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DOI：
10.1002/ar.24393
发表时间：
2020-06
期刊：
Anatomical record (Hoboken, N.J. : 2007)
影响因子：
--
作者：
Jeang L;Cha BJ;Birk DE;Espana EM
通讯作者：
Espana EM
影响因子：
6.5
作者：
Bonod-Bidaud, Christelle;Roulet, Muriel;Ruggiero, Florence
通讯作者：
Ruggiero, Florence
影响因子：
1.6
作者：
Brown, CT;Lin, P;Trinkaus-Randall, V
通讯作者：
Trinkaus-Randall, V
影响因子：
4.4
作者：
Beecher, N;Carlson, C;Quantock, AJ
通讯作者：
Quantock, AJ
影响因子：
4.4
作者：
Bredrup, Cecilie;Stang, Espen;Rodahl, Eyvind
通讯作者：
Rodahl, Eyvind