A replication study of the association between the IL12B promoter allele CTCTAA and susceptibility to cerebral malaria in Thai population.
A replication study of the association between the IL12B promoter allele CTCTAA and susceptibility to cerebral malaria in Thai population.
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DOI：
10.1186/1475-2875-8-290
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发表时间：
2009-12-11
期刊：
影响因子：
3
通讯作者：
Ohashi J
中科院分区：
文献类型：
--
作者：
Naka I;Patarapotikul J;Tokunaga K;Hananantachai H;Tsuchiya N;Ohashi J
白细胞介素-12（IL-12）是由p35和p40亚基组成的异源二聚体细胞因子，被认为在疟疾的发病机制中起重要作用。IL-12 p40亚基由IL-12 B基因编码。据报道，位于rs 17860508的IL 12 B启动子等位基因CTCTAA与非洲人群中脑型疟疾的易感性相关。然而，这种关联迄今尚未在非非洲人群中复制。为了研究CTCTAA等位基因是否与亚洲人群中脑型疟疾的易感性相关，通过PCR直接测序对303名泰国恶性疟原虫疟疾患者（109名脑型疟疾患者和194名轻度疟疾患者）进行了rs 17860508基因分型。CTCTAA等位基因与泰国人群脑型疟疾易感性显著相关（等位基因OR = 1.37;单侧P值= 0.030）。CTCTAA等位基因与脑型疟疾易感性之间的显著关联在东南亚人群中得到证实，这是以前在非洲人群中报道的。
Interleukin-12 (IL-12), a heterodimeric cytokine composed of p35 and p40 subunits, has been thought to play an important role in the pathogenesis of malaria. The IL-12p40 subunit is encoded by the IL12B gene. An IL12B promoter allele, CTCTAA, at rs17860508 has been reported to be associated with susceptibility to cerebral malaria in African populations. However, this association has not so far been replicated in non-African populations. To examine whether the CTCTAA allele is associated with susceptibility to cerebral malaria in Asian populations, 303 Thai patients with Plasmodium falciparum malaria (109 cerebral malaria and 194 mild malaria patients) were genotyped for rs17860508 by PCR-direct sequencing. The CTCTAA allele showed a significant association with susceptibility to cerebral malaria in the Thai population (allelic OR = 1.37; one sided P-value = 0.030). The existence of a significant association between the CTCTAA allele and susceptibility to cerebral malaria was confirmed in Southeast Asian population, which was previously reported in African populations.
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