Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast.
Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast.
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DOI：
10.1038/sj.bjc.6690158
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发表时间：
1999-02
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
坏死是乳腺浸润性癌的常见特征，是由导致梗塞的慢性缺血引起的。尽管以前认为坏死是由于肿瘤中的血液供应普遍较差造成的，但在这项研究中，我们表明坏死存在于远离实际坏死部位的高血管密度局灶区域的肿瘤中。这可能部分解释了之前的观察结果，即坏死与这种疾病的不良预后有关。高度血管生成的肿瘤通常表现出血管从一个肿瘤区域分流到另一个肿瘤区域，这进一步加剧了缺血和肿瘤坏死的形成。我们最近证明，乳腺肿瘤的高灶性微噬细胞浸润与肿瘤血管生成增加和预后不良显着相关，并且巨噬细胞积聚在乳腺肿瘤内血管化不良、缺氧的区域。为了研究乳腺肿瘤中巨噬细胞与慢性缺血（如坏死的存在所反映的）和血管生成的相互作用，我们量化了一系列 109 个连续浸润性乳腺癌中这三个生物学参数的水平。我们发现肿瘤坏死程度与小噬细胞浸润（Mann-Whitney U，P 值= 0.0009；卡方，P 值= 0.01）和血管生成（Mann-Whitney U P 值= 0.0008，卡方 P 值= 0.03）相关。还观察到，坏死是具有侵袭性表型的肿瘤的一个特征，即肿瘤分级高（卡方，P 值 < 0.001）、较大尺寸（Mann–Whitney U，P 值 = 0.003）和低雌激素受体状态（Mann–Whitney U，P 值 = 0.008；卡方，P 值 < 0.008）。因此，我们认为，侵袭性肿瘤在某些区域迅速生长，超出了其血管供应，导致肿瘤内区域长期缺氧，随后导致坏死。反过来，这可能会吸引巨噬细胞进入肿瘤，从而促进血管生成过程，从而导致高水平的血管生成和广泛坏死之间的关联。 © 1999 癌症研究运动
Necrosis is a common feature of invasive carcinoma of the breast and is caused by chronic ischaemia leading to infarction. Although necrosis was previously assumed to be due to a generally poor blood supply in the tumour, in this study we show that it is present in tumours with focal areas of high vascular density situated away from the actual sites of necrosis. This may account, in part, for the previous observation that necrosis is linked to poor prognosis in this disease. Highly angiogenic tumours often display blood vessel shunting from one tumour area to another, which further exacerbates ischaemia and the formation of tumour necrosis. We have recently demonstrated that high focal microphage infiltration into breast tumours is significantly associated with increased tumour angiogenesis and poor prognosis and that the macrophages accumulate in poorly vascularized, hypoxic areas within breast tumours. In order to investigate the interactions of macrophages with chronic ischaemia (as reflected by the presence of necrosis) and angiogenesis in breast tumours, we quantified the levels of these three biological parameters in a series of 109 consecutive invasive breast carcinomas. We found that the degree of tumour necrosis was correlated with both microphage infiltration (Mann–Whitney U, P-value = 0.0009; chi-square, P-value = 0.01) and angiogenesis (Mann–Whitney U P-value = 0.0008, chi square P-value = 0.03). It was also observed that necrosis was a feature of tumours possessing an aggressive phenotype, i.e. high tumour grade (chi-square, P-value < 0.001), larger size (Mann–Whitney U, P-value = 0.003) and low oestrogen receptor status (Mann–Whitney U, P-value = 0.008; chi-square, P-value < 0.008). We suggest, therefore, that aggressive tumours rapidly outgrow their vascular supply in certain areas, leading to areas of prolonged hypoxia within the tumour and, subsequently, to necrosis. This, in turn, may attract macrophages into the tumour, which then contribute to the angiogenic process, giving rise to an association between high levels of angiogenesis and extensive necrosis. © 1999 Cancer Research Campaign
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影响因子：
2.2
作者：
SCANNELL, G;WAXMAN, K;GRANGER, GA
通讯作者：
GRANGER, GA
影响因子：
3.4
作者：
Lee, AHS;Happerfield, LC;Millis, RR
通讯作者：
Millis, RR
乳腺癌血管生成的定量和预后价值--微血管密度、查克利计数和计算机图像分析的比较
影响因子：
7.3
作者：
FOX, SB;LEEK, RD;HARRIS, AL
通讯作者：
HARRIS, AL
影响因子：
82.9
作者：
Helmlinger, G;Yuan, F;Jain, RK
通讯作者：
Jain, RK
DOI：
10.1084/jem.172.6.1535
发表时间：
1990-12-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Clauss M;Gerlach M;Gerlach H;Brett J;Wang F;Familletti PC;Pan YC;Olander JV;Connolly DT;Stern D
通讯作者：
Stern D