Involvement of microRNA in microglia-mediated immune response.
Involvement of microRNA in microglia-mediated immune response.
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DOI：
10.1155/2013/186872
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发表时间：
2013
影响因子：
--
通讯作者：
Pedroso de Lima MC
中科院分区：
文献类型：
--
作者：
Guedes J;Cardoso AL;Pedroso de Lima MC
MicroRNAs （miRNAs）是一类丰富的小非编码RNA分子，在转录后水平的基因表达调控中起重要作用。由于它们能够同时调节不同基因的命运，这些分子特别适合在免疫细胞分化和激活过程中充当关键调节剂，它们的功能障碍可能导致与神经炎症相关的病理状况。最近的研究已经解决了mirna在祖细胞向小胶质细胞分化和激活过程中的作用，旨在阐明成人小胶质细胞的起源以及中枢神经系统（CNS）环境对小胶质细胞表型、健康和疾病的贡献。一些mirna的表达改变与阿尔茨海默病、多发性硬化症和缺血性损伤有关，因此强烈提倡使用这些小分子作为疾病标志物和新的治疗靶点。本文综述了近年来mirna介导的小胶质细胞发育和激活调控的研究进展。我们讨论了特定的mirna在维持和切换小胶质细胞激活状态中的作用，并说明了这类核酸作为炎症的生物标志物和中枢神经系统中调节小胶质细胞行为的新治疗工具的潜力。
MicroRNAs (miRNAs) are an abundant class of small noncoding RNA molecules that play an important role in the regulation of gene expression at the posttranscriptional level. Due to their ability to simultaneously modulate the fate of different genes, these molecules are particularly well suited to act as key regulators during immune cell differentiation and activation, and their dysfunction can contribute to pathological conditions associated with neuroinflammation. Recent studies have addressed the role of miRNAs in the differentiation of progenitor cells into microglia and in the activation process, aiming at clarifying the origin of adult microglia cells and the contribution of the central nervous system (CNS) environment to microglia phenotype, in health and disease. Altered expression of several miRNAs has been associated with Alzheimer's disease, multiple sclerosis, and ischemic injury, hence strongly advocating the use of these small molecules as disease markers and new therapeutic targets. This review summarizes the recent advances in the field of miRNA-mediated regulation of microglia development and activation. We discuss the role of specific miRNAs in the maintenance and switching of microglia activation states and illustrate the potential of this class of nucleic acids both as biomarkers of inflammation and new therapeutic tools for the modulation of microglia behavior in the CNS.
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影响因子：
9.3
作者：
Cribbs DH;Berchtold NC;Perreau V;Coleman PD;Rogers J;Tenner AJ;Cotman CW
通讯作者：
Cotman CW
影响因子：
3.5
作者：
Gaughwin, Philip Michael;Ciesla, Maciej;Bjorkqvist, Maria
通讯作者：
Bjorkqvist, Maria
影响因子：
2.2
作者：
Gentleman, SM;Leclercq, PD;Nicoll, JAR
通讯作者：
Nicoll, JAR
DOI：
10.1046/j.1365-2362.2002.00994.x
发表时间：
2002-05-01
影响因子：
5.5
作者：
Fiala, M;Liu, QN;Vinters, HV
通讯作者：
Vinters, HV
影响因子：
4.8
作者：
Bala, Shashi;Marcos, Miguel;Szabo, Gyongyi
通讯作者：
Szabo, Gyongyi