Acid-Sensitive Magnetic Nanoparticles as Potential Drug Depots.
Acid-Sensitive Magnetic Nanoparticles as Potential Drug Depots.
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DOI：
10.1002/aic.12373
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发表时间：
2011-06
期刊：
影响因子：
3.7
通讯作者：
Pack, Daniel W.
中科院分区：
文献类型：
--
作者：
Wuang, Shy Chyi;Neoh, Koon Gee;Kang, En-Tang;Leckband, Deborah E.;Pack, Daniel W.
关键词：
通过原子转移自由基聚合，成功地将超顺磁性纳米粒子与聚甲基丙烯酸进行官能化，然后与阿霉素（Dox）偶联。由于pH敏感的腙键，在较低的pH和/或较高的温度下，从颗粒中释放Dox的速度和程度高于生理条件下。适当改变pH值和温度可以增加药物从颗粒中的释放。由于释放的药物，这些颗粒在体外被发现对人类乳腺癌细胞具有细胞毒性。这种磁性纳米颗粒具有在生理条件下保留药物并在pH值较低或温度较高的条件下释放药物的潜力，可以通过减少药物对健康组织的副作用而用于磁性药物靶向。此外，它们可以作为热疗剂，在热疗中使用的高温可以触发进一步的药物释放。
Superparamagnetic magnetic nanoparticles were successfully functionalized with poly(methacrylic acid) via atom transfer radical polymerization, followed by conjugation to doxorubicin (Dox). Because of pH-sensitive hydrazone linkages, the rate and extent of Dox release from the particles was higher at a lower pH and/or a higher temperature than at physiological conditions. Appropriate changes to the pH and temperature can increase the drug release from the particles. Because of the released drug, the particles were found to be cytotoxic to human breast cancer cells in vitro. Such magnetic nanoparticles, with the potential to retain drug under physiological conditions and release the drug in conditions where the pH is lower or temperature is higher, may be useful in magnetic drug targeting by reducing the side effects of the drug caused to healthy tissues. In addition, they may serve as hyperthermia agents where the high temperatures used in hyperthermia can trigger further drug release.
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