The Moderating Role of Fatigue Sensitivity in the Relation between Depression and Alcohol and Opioid Misuse among Adults with Chronic Low Back Pain.
The Moderating Role of Fatigue Sensitivity in the Relation between Depression and Alcohol and Opioid Misuse among Adults with Chronic Low Back Pain.
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DOI：
10.1080/21641846.2020.1818933
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Zvolensky MJ
中科院分区：
文献类型：
--
作者：
Manning K;Rogers AH;Garey L;Zvolensky MJ
慢性腰痛是美国第二大残疾原因，通常与滥用阿片类药物和酒精的风险增加有关。慢性腰痛患者的抑郁症与药物使用结果不良有关。从理论上讲，抑郁症对慢性腰痛患者阿片类药物和酒精滥用的影响可能因疲劳敏感性而异。为了对这一理论模型进行实证检验，本研究在 291 名目前使用阿片类药物治疗慢性腰痛的成年人（69.1% 女性，Mage = 45.77 岁，SD = 11.22）中检查了疲劳敏感性作为抑郁症与阿片类药物和酒精滥用之间关系的调节因素。结果表明，疲劳敏感性调节了抑郁对阿片类药物滥用（β=0.60，p=.001，95%CI [0.02，0.06]）和酒精滥用（β=0.45，p=.025，95%CI [0.002，0.03]）的影响。简单斜率的检查表明，对于疲劳敏感度较高的人来说，抑郁症与阿片类药物和酒精滥用之间的关联具有统计学意义，但对于疲劳敏感度较低的人来说，抑郁症与阿片类药物和酒精滥用之间的关联并不显着。总体而言，当前的研究为慢性腰痛成人患者中疲劳敏感性在抑郁与酒精和阿片类药物滥用之间的关系中的调节作用提供了初步的实证支持。
Chronic low back pain is the second leading cause of disability in the United States and is frequently related to increased risk of opioid and alcohol misuse. Depression is associated with poor substance use outcomes among persons with chronic low back pain. Theoretically, the influence of depression on opioid and alcohol misuse among those with chronic low back pain may vary as a function of fatigue sensitivity. To empirically test this theorized model, the current study examined fatigue sensitivity as a moderator for the relation between depression and opioid and alcohol misuse among 291 adults (69.1% female, Mage = 45.77 years, SD = 11.22) with chronic low back pain currently using opioids. Results suggested that fatigue sensitivity moderated the effect of depression on opioid misuse (β=0.60, p= .001, 95%CI [0.02, 0.06]) and alcohol misuse (β=0.45, p= .025, 95%CI [0.002, 0.03]). Examination of simple slopes revealed that the association between depression and opioid and alcohol misuse was statistically significant for those with higher levels of fatigue sensitivity, but not lower levels of fatigue sensitivity. Overall, the current investigation provides initial empirical support for the moderating role of fatigue sensitivity in the relation between depression and alcohol and opioid misuse among adults with chronic low back pain.
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影响因子：
1.9
作者：
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通讯作者：
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