Roles of Pyroptosis-Related Gene Signature in Prediction of Endometrial Cancer Outcomes.
Roles of Pyroptosis-Related Gene Signature in Prediction of Endometrial Cancer Outcomes.
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焦亡相关基因特征在预测子宫内膜癌结果中的作用
DOI：
10.3389/fmed.2022.822806
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发表时间：
2022
影响因子：
3.9
通讯作者：
Yao S
中科院分区：
文献类型：
--
作者：
Chen Y;Liao Y;Du Q;Shang C;Qin S;Lee K;Zou Q;Liu J;Yao S
Endometrial cancer (EC) is one of the most common gynecological malignancies in women, accompanied by the increasing incidence and decreasing age of onset. Pyroptosis plays an important role in the occurrence and development of malignant tumors. However, the relationship between pyroptosis-related genes and tumor prognosis remains unclear. In this study, analyzing the expression levels and survival data of 33 pyroptosis-related genes in the Cancer Genome Atlas (TCGA) between normal samples and tumor samples, we obtained six pyroptosis-related prognostic differentially expressed genes (DEGs). Then, through the least absolute shrinkage and selection operator (LASSO) regression analysis, a gene signature composed of six genes (GPX4, GSDMD, GSDME, IL6, NOD2 and PYCARD) was constructed and divided patients into high- and low-risk groups. Subsequently, Kaplan-Meier (KM) plot, receiver operating characteristic (ROC) curve and principal component analysis (PCA) in two cohorts demonstrated that the gene signature was an efficient independent prognostic indicator. The enrichment analysis and immune infiltration analysis indicated that the high-risk group generally has lower immune infiltrating cells and less active immune function. In short, we constructed and validated a pyroptosis-related gene signature to predict the prognosis of EC, which is correlated to immune infiltration and proposed to help the precise diagnosis and therapy of EC.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
17.1
作者：
Kinde I;Bettegowda C;Wang Y;Wu J;Agrawal N;Shih IeM;Kurman R;Dao F;Levine DA;Giuntoli R;Roden R;Eshleman JR;Carvalho JP;Marie SK;Papadopoulos N;Kinzler KW;Vogelstein B;Diaz LA Jr
通讯作者：
Diaz LA Jr
影响因子：
254.7
作者：
Siegel, Rebecca L.;Miller, Kimberly D.;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
28.2
作者：
Erkes, Dan A.;Cai, Weijia;Aplin, Andrew E.
通讯作者：
Aplin, Andrew E.
影响因子：
24.5
作者：
Berrebi, D;Maudinas, R;Peuchmaur, M
通讯作者：
Peuchmaur, M