Catestatin: Antimicrobial Functions and Potential Therapeutics.
Catestatin: Antimicrobial Functions and Potential Therapeutics.
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catestatin：抗菌功能和潜在的治疗剂。
DOI：
10.3390/pharmaceutics15051550
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发表时间：
2023-05-20
期刊：
影响因子：
5.4
通讯作者：
Mahata SK
中科院分区：
文献类型：
--
作者：
Jati S;Mahata S;Das S;Chatterjee S;Mahata SK
耐药和多重耐药感染的迅速增加对抗菌治疗构成了严重挑战，并造成了全球健康危机。由于抗菌肽（AMP）在整个进化过程中已经逃脱了细菌的耐药性，AMP是一类潜在的耐药性“超级细菌”的替代品。嗜铬粒蛋白A（CgA）衍生肽Catestatin（CST：hCgA 352 -372; bCgA 344 -364）最初于1997年被鉴定为急性烟碱胆碱能拮抗剂。随后，CST被确定为多效性激素。2005年，据报道牛CST的N-末端15个氨基酸（bCST 1 -15 aka cateslytin）发挥抗菌、抗真菌和抗酵母作用，但不显示任何溶血作用。2017年，D-bCST 1 -15（其中L-氨基酸被改变为D-氨基酸）被证明对各种细菌菌株具有非常有效的抗菌作用。除了抗微生物作用之外，D-bCST 1 -15增强了头孢噻肟、阿莫西林和甲氧西林的（加和/协同）抗微生物作用。此外，D-bCST 1 -15既不引发细菌耐药性，也不引起细胞因子释放。本综述将重点介绍CST、bCST 1 -15（又名cateslytin）、D-bCST 1 -15和CST的人类变体（Gly 364 Ser-CST和Pro370 Leu-CST）的抗菌作用; CST在哺乳动物中的进化保守性;以及它们作为耐药性“超级细菌”的治疗方法的潜力。
The rapid increase in drug-resistant and multidrug-resistant infections poses a serious challenge to antimicrobial therapies, and has created a global health crisis. Since antimicrobial peptides (AMPs) have escaped bacterial resistance throughout evolution, AMPs are a category of potential alternatives for antibiotic-resistant “superbugs”. The Chromogranin A (CgA)-derived peptide Catestatin (CST: hCgA352–372; bCgA344–364) was initially identified in 1997 as an acute nicotinic-cholinergic antagonist. Subsequently, CST was established as a pleiotropic hormone. In 2005, it was reported that N-terminal 15 amino acids of bovine CST (bCST1–15 aka cateslytin) exert antibacterial, antifungal, and antiyeast effects without showing any hemolytic effects. In 2017, D-bCST1–15 (where L-amino acids were changed to D-amino acids) was shown to exert very effective antimicrobial effects against various bacterial strains. Beyond antimicrobial effects, D-bCST1–15 potentiated (additive/synergistic) antibacterial effects of cefotaxime, amoxicillin, and methicillin. Furthermore, D-bCST1–15 neither triggered bacterial resistance nor elicited cytokine release. The present review will highlight the antimicrobial effects of CST, bCST1–15 (aka cateslytin), D-bCST1–15, and human variants of CST (Gly364Ser-CST and Pro370Leu-CST); evolutionary conservation of CST in mammals; and their potential as a therapy for antibiotic-resistant “superbugs”.
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影响因子：
3.7
作者：
Zhang D;Shooshtarizadeh P;Laventie BJ;Colin DA;Chich JF;Vidic J;de Barry J;Chasserot-Golaz S;Delalande F;Van Dorsselaer A;Schneider F;Helle K;Aunis D;Prévost G;Metz-Boutigue MH
通讯作者：
Metz-Boutigue MH
影响因子：
4.5
作者：
Corb Aron RA;Abid A;Vesa CM;Nechifor AC;Behl T;Ghitea TC;Munteanu MA;Fratila O;Andronie-Cioara FL;Toma MM;Bungau S
通讯作者：
Bungau S
DOI：
10.1152/ajpgi.00346.2017
发表时间：
2018-07-01
影响因子：
4.5
作者：
Christiansen, Charlotte Bayer;Gabe, Maria Buur Nordskov;Holst, Jens Juul
通讯作者：
Holst, Jens Juul
影响因子：
4.8
作者：
Biswas, Nilima;Rodriguez-Flores, Juan L.;Mahata, Sushil K.
通讯作者：
Mahata, Sushil K.
DOI：
10.1073/pnas.91.20.9297
发表时间：
1994-09-27
影响因子：
11.1
作者：
BROCCHIERI, L;KARLIN, S
通讯作者：
KARLIN, S