Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration.
Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration.
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DOI：
10.1016/j.chom.2017.11.004
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发表时间：
2018-01-10
影响因子：
30.3
通讯作者：
Bäckhed F
中科院分区：
文献类型：
--
作者：
Schroeder BO;Birchenough GMH;Ståhlman M;Arike L;Johansson MEV;Hansson GC;Bäckhed F
饮食强烈影响肠道微生物群的组成，肠道细菌可以影响结肠粘液层，这是将数万亿肠道细菌与宿主分开的物理屏障。然而，西式饮食（WSD）、肠道微生物群组成和肠道粘液层之间的相互作用尚不清楚。在这里，我们发现喂食 WSD 的小鼠结肠微生物群组成发生改变，导致内部粘液层的渗透性增加和生长速度降低。这两种屏障缺陷都可以通过移植食物喂养小鼠的微生物群来预防。此外，我们发现长双歧杆菌的给药足以恢复粘液生长，而纤维菊粉的给药可阻止 WSD 喂养小鼠粘液渗透性的增加。我们假设不同细菌的存在对于正常的粘液功能至关重要。如果在人类身上得到证实，这些发现可能有助于更好地了解粘液层受影响的疾病，例如溃疡性结肠炎。结肠内粘液层将肠道细菌与其宿主分开。施罗德等人。现在发现肠道细菌可以调节西式饮食小鼠粘液层的功能缺陷。这些缺陷可以通过使用益生菌双歧杆菌或益生元纤维菊粉来预防。
Diet strongly affects gut microbiota composition and gut bacteria can influence the colonic mucus layer, a physical barrier that separates trillions of gut bacteria from the host. However, the interplay between a Western style diet (WSD), gut microbiota composition and the intestinal mucus layer is less clear. Here we show that mice fed a WSD have an altered colonic microbiota composition that causes increased penetrability and a reduced growth rate of the inner mucus layer. Both barrier defects can be prevented by transplanting microbiota from chow-fed mice. In addition, we found that administration of Bifidobacterium longum was sufficient to restore mucus growth whereas administration of the fiber inulin prevented increased mucus penetrability in WSD-fed mice. We hypothesize that the presence of distinct bacteria is crucial for proper mucus function. If confirmed in humans, these findings may help to better understand diseases with an affected mucus layer, such as ulcerative colitis. The inner colonic mucus layer separates gut bacteria from their host. Schroeder et al. now find that gut bacteria can mediate functional defects of the mucus layer of mice fed a Western-style diet. The defects can be prevented by application of a probiotic bifidobacteria or the prebiotic fiber inulin.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
DOI：
10.1016/j.jcmgh.2017.04.001
发表时间：
2017-09
影响因子：
7.2
作者：
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作者：
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影响因子：
5.9
作者：
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通讯作者：
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DOI：
10.1073/pnas.1219451110
发表时间：
2013-05-28
影响因子：
11.1
作者：
Everard, Amandine;Belzer, Clara;Cani, Patrice D.
通讯作者：
Cani, Patrice D.