Endogenous Chemerin from PVAT Amplifies Electrical Field-Stimulated Arterial Contraction: Use of the Chemerin Knockout Rat.
Endogenous Chemerin from PVAT Amplifies Electrical Field-Stimulated Arterial Contraction: Use of the Chemerin Knockout Rat.
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DOI：
10.3390/ijms21176392
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发表时间：
2020-09-02
影响因子：
5.6
通讯作者：
Watts SW
中科院分区：
文献类型：
--
作者：
Flood ED;Watts SW
Background: We previously reported that the adipokine chemerin, when added exogenously to the isolated rat mesenteric artery, amplified electrical field-stimulated (EFS) contraction. The Chemerin1 antagonist CCX832 alone inhibited EFS-induced contraction in tissues with but not without perivascular adipose tissue (PVAT). These data suggested indirectly that chemerin itself, presumably from the PVAT, facilitated EFS-induced contraction. We created the chemerin KO rat and now test the focused hypothesis that endogenous chemerin amplifies EFS-induced arterial contraction. Methods: The superior mesenteric artery +PVAT from global chemerin WT and KO female rats, with endothelium and sympathetic nerve intact, were mounted into isolated tissue baths for isometric and EFS-induced contraction. Results: CCX832 reduced EFS (2–20 Hz)-induced contraction in tissues from the WT but not KO rats. Consistent with this finding, the magnitude of EFS-induced contraction was lower in the tissues from the KO vs. WT rats, yet the maximum response to the adrenergic stimulus PE was not different among all tissues. Conclusion: These studies support that endogenous chemerin modifies sympathetic nerve-mediated contraction through Chemerin1, an important finding relative in understanding chemerin’s role in control of blood pressure.
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DOI：
10.1016/j.autneu.2014.11.006
发表时间：
2015-01
期刊：
Autonomic neuroscience : basic & clinical
影响因子：
--
作者：
Brooks VL;Shi Z;Holwerda SW;Fadel PJ
通讯作者：
Fadel PJ
DOI：
10.1161/atvbaha.113.301476
发表时间：
2013-06
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Watts SW;Dorrance AM;Penfold ME;Rourke JL;Sinal CJ;Seitz B;Sullivan TJ;Charvat TT;Thompson JM;Burnett R;Fink GD
通讯作者：
Fink GD
影响因子：
4.8
作者：
Wittamer, V;Grégoire, F;Parmentier, M
通讯作者：
Parmentier, M
影响因子：
4
作者：
Badoer E;Kosari S;Stebbing MJ
通讯作者：
Stebbing MJ
影响因子：
3.5
作者：
Meder, W;Wendland, M;Forssmann, WG
通讯作者：
Forssmann, WG