Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review.
Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review.
复制标题
DOI：
10.1016/j.jare.2018.01.002
复制
发表时间：
2018-05
影响因子：
10.7
通讯作者：
Das UN
中科院分区：
文献类型：
--
作者：
Das UN
花生四烯酸（AA 20:4n-6）是细胞膜的重要成分，可调节细胞膜的流动性。AA经环氧合酶（COX）、脂氧合酶（LOX）和细胞色素P450酶代谢形成多种具有重要生物学作用的代谢物。在所有的作用中，AA在调节血压中的作用及其预防1型和2型糖尿病的能力似乎很有趣。研究表明，AA及其代谢产物，特别是脂素A4 （LXA4）和环氧二碳三烯酸（EETs），是一种有效的抗炎代谢产物，在高血压和糖尿病的病理生物学中具有重要作用。AA、LXA4和EETs调节平滑肌功能和增殖、电压门控离子通道、细胞膜流动性、膜受体、g偶联受体、ppar、自由基生成、一氧化氮形成、炎症和免疫反应，进而参与调节血压和糖尿病的发病机制。本文就AA及其代谢产物LXA4和EETs在高血压、子痫前期和糖尿病病理生物学中的作用进行综述。基于多项证据，我们认为阿司匹林与AA合用可能有助于预防和治疗高血压、子痫前期和糖尿病。
Arachidonic acid (AA 20:4n-6) is an essential component of cell membranes and modulates cell membrane fluidity. AA is metabolized by cyclo-oxygenase (COX), lipoxygenase (LOX) and cytochrome P450 enzymes to form several metabolites that have important biological actions. Of all the actions, role of AA in the regulation of blood pressure and its ability to prevent both type 1 and type 2 diabetes mellitus seems to be interesting. Studies showed that AA and its metabolites especially, lipoxin A4 (LXA4) and epoxyeicosatrienoic acids (EETs), potent anti-inflammatory metabolites, have a crucial role in the pathobiology of hypertension and diabetes mellitus. AA, LXA4 and EETs regulate smooth muscle function and proliferation, voltage gated ion channels, cell membrane fluidity, membrane receptors, G-coupled receptors, PPARs, free radical generation, nitric oxide formation, inflammation, and immune responses that, in turn, participate in the regulation blood pressure and pathogenesis of diabetes mellitus. In this review, role of AA and its metabolites LXA4 and EETs in the pathobiology of hypertension, pre-eclampsia and diabetes mellitus are discussed. Based on several lines of evidences, it is proposed that a combination of aspirin and AA could be of benefit in the prevention and management of hypertension, pre-eclampsia and diabetes mellitus.
登录
查看更多内容
影响因子：
6
作者：
Cleland, SJ;Sattar, N;Connell, JMC
通讯作者：
Connell, JMC
DOI：
10.1016/j.bbagen.2013.12.023
发表时间：
2014-06-01
影响因子：
3
作者：
Cardoso, Henriqueta Dias;dos Santos Junior, Eraldo Fonseca;da Silveira Andrade-da-Costa, Belmira Lara
通讯作者：
da Silveira Andrade-da-Costa, Belmira Lara
DOI：
10.1006/bbrc.2001.5167
发表时间：
2001-07-20
影响因子：
3.1
作者：
Capdevila, JH;Falck, JR
通讯作者：
Falck, JR
DOI：
10.1016/j.plefa.2005.05.003
发表时间：
2005-09-01
影响因子：
3
作者：
Chiang, N;Arita, M;Serhan, CN
通讯作者：
Serhan, CN
DOI：
10.1073/pnas.1508740112
发表时间：
2015-08-11
影响因子：
11.1
作者：
Burrows, Michael P.;Volchkov, Pavel;Chervonsky, Alexander V.
通讯作者：
Chervonsky, Alexander V.