Metal limitation and toxicity at the interface between host and pathogen.
Metal limitation and toxicity at the interface between host and pathogen.
复制标题
DOI：
10.1111/1574-6976.12087
复制
发表时间：
2014-11
影响因子：
11.3
通讯作者：
Skaar EP
中科院分区：
文献类型：
--
作者：
Becker KW;Skaar EP
金属是许多对病原体和宿主都至关重要的基本过程所需的辅助因子。它们在负责 DNA 复制和转录、缓解氧化应激和细胞呼吸的酶中协调。然而，过量的过渡金属可能有毒，因为它们能够引起自发的氧化还原循环并破坏正常的代谢过程。脊椎动物已经进化出复杂的机制来限制某些关键金属的可用性，同时用其他金属的抗菌浓度淹没感染部位。为了争夺宿主体内有限的金属，同时防止金属毒性，病原体开发了一系列金属调节、获取和流出系统。本综述将涵盖病原菌识别和应对宿主引起的金属稀缺和毒性的机制。
Metals are required cofactors for numerous fundamental processes that are essential to both pathogen and host. They are coordinated in enzymes responsible for DNA replication and transcription, relief from oxidative stress, and cellular respiration. However, excess transition metals can be toxic due to their ability to cause spontaneous, redox cycling and disrupt normal metabolic processes. Vertebrates have evolved intricate mechanisms to limit the availability of some crucial metals while concurrently flooding sites of infection with antimicrobial concentrations of other metals. To compete for limited metal within the host while simultaneously preventing metal toxicity, pathogens have developed a series of metal regulatory, acquisition, and efflux systems. This review will cover the mechanisms by which pathogenic bacteria recognize and respond to host-induced metal scarcity and toxicity.
登录
查看更多内容
影响因子：
6.7
作者：
Citiulo F;Jacobsen ID;Miramón P;Schild L;Brunke S;Zipfel P;Brock M;Hube B;Wilson D
通讯作者：
Wilson D
影响因子：
14.8
作者：
Chaturvedi, Kaveri S.;Hung, Chia S.;Crowley, Jan R.;Stapleton, Ann E.;Henderson, Jeffrey P.
通讯作者：
Henderson, Jeffrey P.
影响因子：
6.7
作者：
Achouiti A;Vogl T;Urban CF;Röhm M;Hommes TJ;van Zoelen MA;Florquin S;Roth J;van 't Veer C;de Vos AF;van der Poll T
通讯作者：
van der Poll T
影响因子：
3.2
作者：
Bonnah, RA;Schryvers, AB
通讯作者：
Schryvers, AB
DOI：
10.1093/infdis/jis272
发表时间：
2012-06
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Anderson AS;Scully IL;Timofeyeva Y;Murphy E;McNeil LK;Mininni T;Nuñez L;Carriere M;Singer C;Dilts DA;Jansen KU
通讯作者：
Jansen KU