The ring between ring fingers (RBR) protein family.
The ring between ring fingers (RBR) protein family.
复制标题
环手指（RBR）蛋白质家族之间的环。
DOI：
10.1186/gb-2007-8-3-209
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发表时间：
2007
期刊：
影响因子：
12.3
通讯作者：
Hauser MT
中科院分区：
文献类型：
--
作者：
Eisenhaber B;Chumak N;Eisenhaber F;Hauser MT
概述了在发育和疾病中调节各种蛋白质相互作用的大的和功能多样的RBR蛋白质家族。RING FING(RBR)结构域家族的蛋白质由三组特定聚集的半胱氨酸和组氨酸残基(通常为八个)组成。氨基末端的环结构域(N环)结合两个锌离子并折叠成经典的交叉花括号环指，而羧基末端的环结构域(C环)只涉及一个锌离子。中心环区的三维结构，即IBR结构域，仍然没有解决。在单细胞和多细胞真核生物及其一些病毒的基因组中已发现约400个编码RBR蛋白的基因，但尚未在古菌或细菌中发现该家族。根据RBR片段的系统发育关系及其序列结构的保守性，将RBR蛋白分为15个主要亚家族(除一些孤儿外)。RBR结构域介导蛋白质之间的相互作用，RBR蛋白的一部分被证明具有E3泛素连接酶的功能。RBR蛋白因参与帕金森病、路易体痴呆、阿尔茨海默病等疾病，以及对一些细胞内细菌病原体的易感性而引起人们的兴趣。在这里，我们介绍了含有RBR结构域的蛋白质及其亚细胞定位、附加结构域、功能、特异性和调节的概述。
An overview of the large and functionally diverse RBR protein family that mediates protein-protein interactions of various kinds in development and disease. Proteins of the ring between ring fingers (RBR)-domain family are characterized by three groups of specifically clustered (typically eight) cysteine and histidine residues. Whereas the amino-terminal ring domain (N-RING) binds two zinc ions and folds into a classical cross-brace ring finger, the carboxy-terminal ring domain (C-RING) involves only one zinc ion. The three-dimensional structure of the central ring domain, the IBR domain, is still unsolved. About 400 genes coding for RBR proteins have been identified in the genomes of uni- and multicellular eukaryotes and some of their viruses, but the family has not been found in archaea or bacteria. The RBR proteins are classified into 15 major subfamilies (besides some orphan cases) by the phylogenetic relationships of the RBR segments and the conservation of their sequence architecture. The RBR domain mediates protein-protein interactions and a subset of RBR proteins has been shown to function as E3 ubiquitin ligases. RBR proteins have attracted interest because of their involvement in diseases such as parkinsonism, dementia with Lewy bodies, and Alzheimer's disease, and in susceptibility to some intracellular bacterial pathogens. Here, we present an overview of the RBR-domain containing proteins and their subcellular localization, additional domains, function, specificity, and regulation.
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影响因子：
3.5
作者：
Cookson, MR;Lockhart, PJ;Farrer, MJ
通讯作者：
Farrer, MJ
影响因子：
4.8
作者：
Ardley, HC;Tan, NGS;Robinson, PA
通讯作者：
Robinson, PA
影响因子：
21.3
作者：
Fallon, Lara;Belanger, Catherine M. L.;Fon, Edward A.
通讯作者：
Fon, Edward A.
DOI：
10.1093/protein/15.9.745
发表时间：
2002-09-01
期刊：
PROTEIN ENGINEERING
影响因子：
--
作者：
Cserzö, M;Eisenhaber, F;Simon, I
通讯作者：
Simon, I
影响因子：
14.9
作者：
Chenna, R;Sugawara, H;Thompson, JD
通讯作者：
Thompson, JD