Molecular cloning of Xenopus fibrillarin, a conserved U3 small nuclear ribonucleoprotein recognized by antisera from humans with autoimmune disease
Molecular cloning of Xenopus fibrillarin, a conserved U3 small nuclear ribonucleoprotein recognized by antisera from humans with autoimmune disease
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非洲爪蟾原纤维蛋白的分子克隆,这是一种保守的 U3 小核核糖核蛋白,可被自身免疫性疾病患者的抗血清识别
DOI:
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发表时间:
1990
影响因子:
5.3
通讯作者:
M. Caizergues
中科院分区:
文献类型:
--
作者:
B. Lapeyre;P. Mariottini;C. Mathieu;P. Ferrer;F. Amaldi;F. Amalric;M. Caizergues
Autoantibodies against U3 small nuclear ribonucleoprotein are associated with scleroderma autoimmune disease. They were shown to react with fibrillarin, a 34- to 36-kilodalton protein that has been detected in all eukaryotes tested from humans to yeasts. We isolated a 1.6-kilobase cDNA encoding fibrillarin from a Xenopus laevis cDNA library. The protein contains a 79-residue-long Gly-Arg-rich domain in its N-terminal region and a putative RNA-binding domain with ribonucleoprotein consensus sequence in its central portion. This is the first report of cloning of fibrillarin, and the deduced protein sequence is in agreement with the involvement of the protein in a ribonucleoprotein particle.
影响因子:
14.9
作者:
Jeppesen,C;Stebbins-Boaz,B;Gerbi,SA
通讯作者:
Gerbi,SA
DOI:
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发表时间:
1985
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
Lischwe,MA;Ochs,RL;Reddy,R;Cook,RG;Yeoman,LC;Tan,EM;Reichlin,M;Busch,H
通讯作者:
Busch,H
影响因子:
5.3
作者:
Parker,KA;Steitz,JA
通讯作者:
Steitz,JA