Coding in the mammalian gustatory system.

Coding in the mammalian gustatory system.
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DOI:
10.1016/j.tins.2010.04.002
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发表时间:
2010-07
影响因子:
15.9
通讯作者:
Simon SA
Simon SA
中科院分区:
医学1区
文献类型:
--
作者:
Carleton A;Accolla R;Simon SA

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要理解味觉生理学及相关机能障碍,了解置于口腔中的刺激如何在周边以及与味觉相关的大脑中枢进行编码是很重要的。对不同味觉受体的识别,连同针对味觉刺激的电生理记录和行为评估表明,关于不同味觉模式(例如,甜与苦)的信息是通过分离的通路从周边传递到大脑的。相比之下,整个大脑中的味觉神经元具有更广泛的调谐性,这表明神经元集群对味觉品质进行编码。此处综述的近期证据表明,味觉刺激的编码不是一成不变的,而是取决于多种因素,包括食欲调节分子和联想学习。
To understand gustatory physiology and associated dysfunctions it is important to know how stimuli placed in the mouth are encoded both in the periphery and in taste-related brain centres. The identification of distinct taste receptors, together with electrophysiological recordings and behavioural assessments in response to taste stimuli, suggest that information about distinct taste modalities (e.g., sweet versus bitter) are transmitted from the periphery to the brain via segregated pathways. In contrast, gustatory neurons throughout the brain are more broadly tuned, indicating that ensembles of neurons encode taste qualities. Recent evidence reviewed here suggests that the coding of gustatory stimuli is not immutable, but is dependant on a variety of factors including appetite regulating molecules and associative learning.
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