Memory retrieval of smoking-related images induce greater insula activation as revealed by an fMRI-based delayed matching to sample task.
Memory retrieval of smoking-related images induce greater insula activation as revealed by an fMRI-based delayed matching to sample task.
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DOI：
10.1111/adb.12112
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发表时间：
2015-03
影响因子：
3.4
通讯作者：
Stern CE
中科院分区：
文献类型：
--
作者：
Janes AC;Ross RS;Farmer S;Frederick BB;Nickerson LD;Lukas SE;Stern CE
尼古丁依赖是一种慢性且难以治疗的疾病。虽然环境刺激与吸烟沉淀渴望和复发，它是未知的，是否吸烟线索的认知处理不同于中性刺激。为了评估吸烟相关和中性刺激之间的工作记忆差异，我们在尼古丁依赖参与者中同时进行了延迟匹配样本（DMS）任务和功能磁共振成像（fMRI）。DMS任务评估工作记忆的编码、维持和提取阶段的大脑激活。吸烟图像诱导显着更主观的渴望，和更大的中线皮层激活编码过程中相比，中性刺激，内容相似，但缺乏吸烟成分。参与维持尼古丁依赖的神经元在成功检索先前观看的吸烟与中性图像期间是活跃的。相比之下，中性图像需要更多的前额叶皮层介导的积极维护期间的维护。这些发现表明，不同的大脑区域参与了与吸烟相关的图像和中性图像的工作记忆的不同阶段。重要的是，这些结果暗示了吸烟相关刺激的提取，这与吸烟成瘾中的新角色有关。
Nicotine dependence is a chronic and difficult to treat disorder. While environmental stimuli associated with smoking precipitate craving and relapse, it is unknown whether smoking cues are cognitively processed differently than neutral stimuli. To evaluate working memory differences between smoking-related and neutral stimuli, we conducted a delay-match-to-sample (DMS) task concurrently with functional magnetic resonance imaging (fMRI) in nicotine dependent participants. The DMS task evaluates brain activation during the encoding, maintenance, and retrieval phases of working memory. Smoking images induced significantly more subjective craving, and greater midline cortical activation during encoding in comparison to neutral stimuli that were similar in content yet lacked a smoking component. The insula, which is involved in maintaining nicotine dependence, was active during the successful retrieval of previously viewed smoking vs. neutral images. In contrast, neutral images required more prefrontal cortex-mediated active maintenance during the maintenance period. These findings indicate that distinct brain regions are involved in the different phases of working memory for smoking-related vs. neutral images. Importantly the results implicate the insula in the retrieval of smoking-related stimuli, which is relevant given the insula’s emerging role in addiction.
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影响因子：
4.2
作者：
Heatherton, Todd F.;Wyland, Carrie L.;Kelley, William M.
通讯作者：
Kelley, William M.
影响因子：
7.6
作者：
Franklin, Teresa R.;wang, Ze;Childress, Anna Rose
通讯作者：
Childress, Anna Rose
DOI：
10.1016/j.cogbrainres.2004.06.014
发表时间：
2004-11-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Cairo, TA;Liddle, PF;Ngan, ETC
通讯作者：
Ngan, ETC
影响因子：
5.3
作者：
LoPresti, Matthew L.;Schon, Karin;Stern, Chantal E.
通讯作者：
Stern, Chantal E.
影响因子：
10.6
作者：
Forget, Benoit;Pushparaj, Abhiram;Le Foll, Bernard
通讯作者：
Le Foll, Bernard