Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults.
Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults.
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DOI：
10.3945/jn.112.171520
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
HALCyon Study Team
中科院分区：
文献类型：
--
作者：
Alfred T;Ben-Shlomo Y;Cooper R;Hardy R;Deary IJ;Elliott J;Harris SE;Hyppönen E;Kivimaki M;Kumari M;Maddock J;Power C;Starr JM;Kuh D;Day IN;HALCyon Study Team
Several investigations have observed positive associations between good nutritional status, as indicated by micronutrients, and cognitive measures; however, these associations may not be causal. Genetic polymorphisms that affect nutritional biomarkers may be useful for providing evidence for associations between micronutrients and cognitive measures. As part of the Healthy Ageing across the Life Course (HALCyon) program, men and women aged between 44 and 90 y from 6 UK cohorts were genotyped for polymorphisms associated with circulating concentrations of iron [rs4820268 transmembrane protease, serine 6 (TMPRSS6) and rs1800562 hemochromatosis (HFE)], vitamin B-12 [(rs492602 fucosyltransferase 2 (FUT2)], vitamin D ([rs2282679 group-specific component (GC)] and β-carotene ([rs6564851 beta-carotene 15,15'-monooxygenase 1 (BCMO1)]. Meta-analysis was used to pool within-study effects of the associations between these polymorphisms and the following measures of cognitive capability: word recall, phonemic fluency, semantic fluency, and search speed. Among the several statistical tests conducted, we found little evidence for associations. We found the minor allele of rs1800562 was associated with poorer word recall scores [pooled β on Z-score for carriers vs. noncarriers: −0.05 (95% CI: −0.09, −0.004); P = 0.03, n = 14,105] and poorer word recall scores for the vitamin D–raising allele of rs2282679 [pooled β per T allele: −0.03 (95% CI: −0.05, −0.003); P = 0.03, n = 16,527]. However, there was no evidence for other associations. Our findings provide little evidence to support associations between these genotypes and cognitive capability in older adults. Further investigations are required to elucidate whether the previous positive associations from observational studies between circulating measures of these micronutrients and cognitive performance are due to confounding and reverse causality.
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影响因子：
3.5
作者：
Ahn J;Yu K;Stolzenberg-Solomon R;Simon KC;McCullough ML;Gallicchio L;Jacobs EJ;Ascherio A;Helzlsouer K;Jacobs KB;Li Q;Weinstein SJ;Purdue M;Virtamo J;Horst R;Wheeler W;Chanock S;Hunter DJ;Hayes RB;Kraft P;Albanes D
通讯作者：
Albanes D
影响因子：
5
作者：
Haveman-Nies, A;de Groot, LPGM;van Staveren, WA
通讯作者：
van Staveren, WA
影响因子：
5
作者：
Jama, JW;Launer, LJ;Hofman, A
通讯作者：
Hofman, A
影响因子：
158.5
作者：
Adams, PC;Reboussin, DM;Thomson, E
通讯作者：
Thomson, E
DOI：
10.1073/pnas.192585799
发表时间：
2002-11-12
影响因子：
11.1
作者：
Atamna, H;Killilea, DW;Ames, BN
通讯作者：
Ames, BN