Nodes of Ranvier and axon initial segments are ankyrin G-dependent domains that assemble by distinct mechanisms.
Nodes of Ranvier and axon initial segments are ankyrin G-dependent domains that assemble by distinct mechanisms.
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DOI：
10.1083/jcb.200612012
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发表时间：
2007-06-04
期刊：
影响因子：
--
通讯作者：
Salzer JL
中科院分区：
文献类型：
--
作者：
Dzhashiashvili Y;Zhang Y;Galinska J;Lam I;Grumet M;Salzer JL
Axon initial segments (AISs) and nodes of Ranvier are sites of action potential generation and propagation, respectively. Both domains are enriched in sodium channels complexed with adhesion molecules (neurofascin [NF] 186 and NrCAM) and cytoskeletal proteins (ankyrin G and βIV spectrin). We show that the AIS and peripheral nervous system (PNS) nodes both require ankyrin G but assemble by distinct mechanisms. The AIS is intrinsically specified; it forms independent of NF186, which is targeted to this site via intracellular interactions that require ankyrin G. In contrast, NF186 is targeted to the node, and independently cleared from the internode, by interactions of its ectodomain with myelinating Schwann cells. NF186 is critical for and initiates PNS node assembly by recruiting ankyrin G, which is required for the localization of sodium channels and the entire nodal complex. Thus, initial segments assemble from the inside out driven by the intrinsic accumulation of ankyrin G, whereas PNS nodes assemble from the outside in, specified by Schwann cells, which direct the NF186-dependent recruitment of ankyrin G.
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DOI：
10.1083/jcb.200110003
发表时间：
2002-01-21
期刊：
The Journal of cell biology
影响因子：
--
作者：
Komada M;Soriano P
通讯作者：
Soriano P
DOI：
10.1023/a:1007053411667
发表时间：
1999-04-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
Ching, W;Zanazzi, G;Salzer, JL
通讯作者：
Salzer, JL
DOI：
10.1083/jcb.137.3.703
发表时间：
1997-05-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Garver TD;Ren Q;Tuvia S;Bennett V
通讯作者：
Bennett V
DOI：
10.1073/pnas.042601799
发表时间：
2002-02-19
影响因子：
11.1
作者：
Jenkins, SM;Bennett, V
通讯作者：
Bennett, V
影响因子：
16.2
作者：
Eshed, Y;Feinberg, K;Peles, E
通讯作者：
Peles, E