Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease.
Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease.
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沿血管周围的扩散显示有证据支持帕金森病患者的淋巴功能受损。
DOI：
10.1016/j.parkreldis.2021.06.004
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发表时间：
2021-08
影响因子：
4.1
通讯作者：
Claassen DO
中科院分区：
文献类型：
--
作者：
McKnight CD;Trujillo P;Lopez AM;Petersen K;Considine C;Lin YC;Yan Y;Kang H;Donahue MJ;Claassen DO
Reduced diffusion along perivascular spaces in adults with Alzheimer’s-disease-related-dementias has been reported and attributed to reduced glymphatic function. To apply quantitative measures of diffusion along, and orthogonal to, perivascular spaces in a cohort of older adults with and without clinical symptoms of alpha-synuclein related neurodegeneration. 181 adults with Parkinson disease (PD) or essential tremor (ET) additionally sub-classified by the presence of cognitive impairment underwent 3 Tesla MRI. Diffusion-tensor-imaging (spatial resolution=2×2×2 mm; b-value=1000 s/mm2; directions=33) measures of diffusion (mm2/s) parallel and orthogonal to perivascular spaces at the level of the medullary veins, and the ratio of these measures (ALPS-index), were calculated. Regions were identified by a board-certified neuroradiologist from T1-weighted and T2-weighted MRI. Evaluations of motor impairment and mild cognitive impairment (MCI) were interpreted by a board-certified neurologist and neuropsychologist, respectively. Multiple regression with false discovery rate correction was applied to understand how diffusion metrics related to (i) disease category (PD vs. ET), (ii) cognition (MCI status), and (iii) white matter disease severity from the Fazekas score. The ALPS-index was reduced in PD compared to ET participants (p=0.037). No association between the ALPS-index and MCI status, but an inverse association between the ALPS-index and Fazekas score (p=0.002), was observed. The ALPS-index was inversely associated with age (p=0.007). Diffusion aberrations near perivascular spaces are evident in patients with alpha-synuclein related neurodegenerative disorders, and are related to age and white matter disease severity.
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影响因子：
2.1
作者：
Taoka T;Naganawa S
通讯作者：
Naganawa S
DOI：
10.1126/science.1241224
发表时间：
2013-10-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Xie L;Kang H;Xu Q;Chen MJ;Liao Y;Thiyagarajan M;O'Donnell J;Christensen DJ;Nicholson C;Iliff JJ;Takano T;Deane R;Nedergaard M
通讯作者：
Nedergaard M
影响因子：
7.7
作者：
Absinta M;Ha SK;Nair G;Sati P;Luciano NJ;Palisoc M;Louveau A;Zaghloul KA;Pittaluga S;Kipnis J;Reich DS
通讯作者：
Reich DS
影响因子：
17.1
作者：
Iliff JJ;Wang M;Liao Y;Plogg BA;Peng W;Gundersen GA;Benveniste H;Vates GE;Deane R;Goldman SA;Nagelhus EA;Nedergaard M
通讯作者：
Nedergaard M
DOI：
10.1073/pnas.1721694115
发表时间：
2018-04-24
影响因子：
11.1
作者：
Shokri-Kojori E;Wang GJ;Wiers CE;Demiral SB;Guo M;Kim SW;Lindgren E;Ramirez V;Zehra A;Freeman C;Miller G;Manza P;Srivastava T;De Santi S;Tomasi D;Benveniste H;Volkow ND
通讯作者：
Volkow ND