Attention-Deficit/Hyperactivity Disorder And Inflammation: What Does Current Knowledge Tell Us? A Systematic Review.

Attention-Deficit/Hyperactivity Disorder And Inflammation: What Does Current Knowledge Tell Us? A Systematic Review.
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DOI:
10.3389/fpsyt.2017.00228
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发表时间:
2017
影响因子:
4.7
通讯作者:
Teixeira AL
Teixeira AL
中科院分区:
医学3区
文献类型:
--
作者:
Anand D;Colpo GD;Zeni G;Zeni CP;Teixeira AL

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注意缺陷/多动障碍(ADHD)是一种干扰发育和/或功能的复杂疾病。我们的目的是调查多动症和炎症之间的潜在联系。我们对人类研究进行了系统回顾,测量了ADHD患者的炎症标志物。通过检索PUBMED、MEDLINE、EMBASE、PSYCHINFO、COCHRANE和SCOPUS数据库,检索2016年9月之前发表的同行评审期刊,确定了这些研究。我们测量了细胞因子基因表达和蛋白质。14篇论文符合纳入标准。7项研究评估了细胞因子基因多态性与多动症的关系,6项研究测量了血液中的细胞因子水平。一项研究分析了ADHD患者脑脊液中细胞因子的存在。总之,这些研究表明炎症在ADHD发病机制中可能起作用,尽管结果存在显著的异质性和矛盾。有证据表明多动症与炎症过程有关,但还需要更多的研究。
Attention-deficit/hyperactivity disorder (ADHD) is a complex condition that interferes with development and/or functioning. Our objective is to investigate the potential association between ADHD and inflammation. We conducted a systematic review of human studies measuring inflammatory markers in ADHD. The studies were identified by searching PUBMED, MEDLINE, EMBASE, PSYCHINFO, COCHRANE, and SCOPUS databases for peer-reviewed journals published until September 2016. We included cytokine gene expression and protein measured. Fourteen papers met the inclusion criteria. Seven studies evaluated the association of cytokine gene polymorphisms in ADHD, and six studies measured cytokines levels in blood. One study analyzed the presence of cytokines in cerebrospinal fluid in patients with ADHD. Altogether, these studies indicate a possible role of inflammation in ADHD pathogenesis, despite the significant heterogeneity and contradictory results. Evidence points to the association of ADHD with inflammatory processes, but more studies are warranted.
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期刊: ADHD-ATTENTION DEFICIT AND HYPERACTIVITY DISORDERS
影响因子: --
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