Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity.
Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity.
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1 型一氧化氮合酶调节心肌细胞收缩性和钙处理：与低内在有氧能力相关。
DOI：
10.1097/hjr.0b013e3280128bef
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Ellingsen,Øyvind
中科院分区：
文献类型：
--
作者：
Høydal,MortenA;Wisløff,Ulrik;Kemi,OleJ;Britton,StevenL;Koch,LaurenG;Smith,GodfreyL;Ellingsen,Øyvind
BackgroundThe neuronal isoform of nitric oxide synthase (NOS-1) may be an important regulator of cardiac contractility by modifying calcium release and uptake from sarcoplasmic reticulum. Our working hypothesis was that NOS-1 modulates cardiomyocyte contractility more markedly in rat lines with low versus high congenital aerobic fitness.Methods and resultsRats performed high-intensity interval treadmill running 5 days per week over 8 weeks; age-matched sedentary rats served as controls. At baseline before the training program, aerobic fitness measured as maximal oxygen uptake was 30% higher, and cardiomyocyte contractility measured as fractional shortening 42% higher in high than in low congenital aerobic fitness rats. Training markedly increased aerobic fitness as well as cardiomyocyte contractility, relaxation and corresponding changes in calcium transient in both lines. Selective inhibition of NOS-1 increased cardiomyocyte contractility (12–43%) and calcium transient amplitude (10–28%), prolonged time to 50% relengthening (13–52%) and time to 50% calcium decay (17–35%), in all groups. Interestingly, NOS-1-inhibition abolished the difference in systolic events between low and high congenital aerobic fitness whereas no such findings occurred in diastolic parameters.ConclusionNOS-1-derived nitric oxide production is a modulator of cardiomyocyte contractile performance and calcium handling in rats. It accounts for some of the difference between rats with low versus high congenital aerobic fitness, whereas it contributes little during adaptation to exercise training.
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DOI：
10.1073/pnas.0404136101
发表时间：
2004-11-09
影响因子：
11.1
作者：
Khan, SA;Lee, K;Hare, JM
通讯作者：
Hare, JM
慢性运动改变离体大鼠心肌细胞的收缩性和形态。
DOI：
10.1152/ajpcell.1993.264.5.c1180
发表时间：
1993
期刊：
The American journal of physiology
影响因子：
--
作者：
Moore,RL;Musch,TI;Yelamarty,RV;ScadutoJr,RC;Semanchick,AM;Elensky,M;Cheung,JY
通讯作者：
Cheung,JY
一氧化氮合酶的缺乏会抑制心肌中离子转运酶的功能。
DOI：
10.1016/s0006-291x(02)00599-5
发表时间：
2002
影响因子：
3.1
作者：
Zhou,Lan;Burnett,ArthurL;Huang,PaulL;Becker,LewisC;Kuppusamy,Periannan;Kass,DavidA;KevinDonahue,J;Proud,David;Sham,JamesSK;Dawson,TedM;Xu,KaiY
通讯作者：
Xu,KaiY
影响因子：
37.8
作者：
Ashley, EA;Sears, CE;Casadei, B
通讯作者：
Casadei, B
影响因子：
3.9
作者：
Brown, GC;McBride, AG;Borutaite, V
通讯作者：
Borutaite, V