Trends in oral contraceptive and intrauterine device use among reproductive-aged women in the US from 1999 to 2017.

Trends in oral contraceptive and intrauterine device use among reproductive-aged women in the US from 1999 to 2017.
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从1999年到2017年,美国育龄妇女口服避孕药和宫内节育器的使用趋势。

DOI:
10.1007/s10552-021-01410-8
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发表时间:
2021-06
期刊:
Cancer causes & control : CCC
影响因子:
--
通讯作者:
Trabert B
Trabert B
中科院分区:
其他
文献类型:
--
作者:
King LA;Michels KA;Graubard BI;Trabert B

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自 20 世纪 60 年代以来,口服避孕药 (OC) 使用量的增加反映了卵巢癌发病率的下降。宫内节育器 (IUD) 对癌症风险的影响尚不明确。随着获取途径的改善和选择的增加,我们必须考虑改变使用方式会如何影响癌症风险。来自国家健康和营养检查调查(NHANES,1999-2016)和国家家庭成长调查(NSFG,2006-2017)的全国代表性数据用于评估绝经前妇女随时间推移的避孕药具使用情况(NHANES N=13,179;NSFG N=26,262)。对趋势进行了总体评估,并按种族、年龄、怀孕史、教育程度和体重指数进行了评估。自我报告的宫内节育器使用量年均绝对增长率为 0.81% (NSFG),而 OC 使用量在 NSFG 中下降了 0.49%,在 NHANES 中下降了 0.47%。这代表 NSFG 中 OC 使用量显着下降 [年度百分比变化 (APC) -2.2% (95%CI -3.4, -1.0%),P<0.01]。 NHANES 中 OC 使用趋势因妊娠史而有所不同(P 交互=0.054)。相比之下,宫内节育器的使用每年增加 6.2% [(1.4, 11.2%),P=0.03],并且因妊娠史而异(P 交互<0.01)。未怀孕女性宫内节育器使用量每年增加 11.0% [(2.6, 20.1%), P=0.02],而之前怀孕的女性则增加 5.2% [(0.4, 10.2%), P=0.04]。 2015-2017 年,宫内节育器的使用率为 76.5% 激素(71.1, 81.8%)和 22.9% 铜(17.4, 28.3%),其中肥胖女性激素宫内节育器的使用率更高 [89.4%, (82.9, 95.9%)]。美国绝经前女性宫内节育器使用量的增加超过了口服避孕药使用量的下降。随着越来越多的女性获得可能降低风险的避孕药具,妇科癌症风险可能会降低。
Since the 1960s, increasing oral contraceptive (OC) use has mirrored decreasing ovarian cancer incidence. The impact of intrauterine devices (IUDs) on cancer risk is less well established. With improved access and increased options, we must consider how changing usage can affect cancer risks. Nationally representative data from the National Health and Nutrition Examination Survey (NHANES, 1999–2016) and the National Survey for Family Growth (NSFG, 2006–2017) were used to evaluate contraceptive use over time in premenopausal women (NHANES N=13,179; NSFG N=26,262). Trends were assessed overall and by race, age, pregnancy history, education, and body mass index. The average annual absolute increase in self-reported IUD use was 0.81% (NSFG), while OC use decreased 0.49% in NSFG and 0.47% in NHANES. This represents a significant decrease in OC use in NSFG [annual percent change (APC) −2.2% (95%CI −3.4, −1.0%), P<0.01]. Trends in OC use varied somewhat by pregnancy history in NHANES (P-interaction=0.054). In contrast, IUD use increased 6.2% annually [(1.4, 11.2%), P=0.03] and varied significantly by pregnancy history (P-interaction<0.01). Nulligravid women increased IUD use 11.0% annually [(2.6, 20.1%), P=0.02] compared to women with prior pregnancy at 5.2% [(0.4, 10.2%), P=0.04]. In 2015–2017, IUD use was 76.5% hormonal (71.1, 81.8%) and 22.9% copper (17.4, 28.3%) with greater hormonal IUD use in obese women [89.4%, (82.9, 95.9%)]. Increasing IUD use outpaced declining OC use in premenopausal US women. There may be a resulting decreased gynecologic cancer risk as more women gain access to potentially risk-reducing contraceptives.
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