High-resolution 1H NMR imaging of regional ischemia in the isolated perfused rabbit heart at 4.7 T.

High-resolution 1H NMR imaging of regional ischemia in the isolated perfused rabbit heart at 4.7 T.
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4.7 T 下离体灌注兔心脏局部缺血的高分辨率 1H NMR 成像。

DOI:
10.1002/mrm.1910210118
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发表时间:
1991
影响因子:
3.3
通讯作者:
Blackband,SJ
Blackband,SJ
中科院分区:
医学3区
文献类型:
--
作者:
Chatham,JC;Ackerman,S;Blackband,SJ

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在心脏停搏诱导局部缺血之前和之后,记录离体灌注兔心脏的高分辨率1H NMR图像。在T2加权图像上,缺血区域比周围组织更暗,从图像中测量到T2降低28%。注入NMR造影剂表明T2加权图像上的低信号区域来自缺血区域,这通过心脏的组织学分析进一步证实。这表明缺血区T2降低可能是水区室化改变的结果。这是可能的,这些变化可能被用来遵循缺血期间组织损伤的演变,因此提供有关的信息之间的过渡可逆到不可逆的损伤在离体灌注心脏。出版社:Academic Press,Inc.
High‐resolution1H NMR images of the isolated perfused rabbit heart were recorded before and after the induction of regional ischemia while the heart was arrested. On T2‐weighted images the ischemic region appeared darker than the surrounding tissue and a 28% reduction in T2was measured from the images. Infusion of an NMR contrast agent demonstrated that the hypointense region on the T2‐weighted image was from the ischemic region, which was further confirmed by histological analysis of the heart. It is proposed that the decreased T2in the ischemic region may be a consequence of changes in water compartmentalization. It is possible that these changes may be used to follow the evolution of tissue injury during ischemia, and therefore provide information regarding the transition between reversible to irreversible injury in the isolated perfused heart. © 1991 Academic Press, Inc.
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