Rational Design of Peptide-Based Inhibitors Disrupting Protein-Protein Interactions.
Rational Design of Peptide-Based Inhibitors Disrupting Protein-Protein Interactions.
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破坏蛋白质-蛋白质相互作用的基于肽的抑制剂的合理设计
DOI：
10.3389/fchem.2021.682675
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发表时间：
2021
影响因子：
5.5
通讯作者：
Lu S
中科院分区：
文献类型：
--
作者：
Wang X;Ni D;Liu Y;Lu S
Protein-protein interactions (PPIs) are well-established as a class of promising drug targets for their implications in a wide range of biological processes. However, drug development toward PPIs is inevitably hampered by their flat and wide interfaces, which generally lack suitable pockets for ligand binding, rendering most PPI systems “undruggable.” Here, we summarized drug design strategies for developing peptide-based PPI inhibitors. Importantly, several quintessential examples toward well-established PPI targets such as Bcl-2 family members, p53-MDM2, as well as APC-Asef are presented to illustrate the detailed schemes for peptide-based PPI inhibitor development and optimizations. This review supplies a comprehensive overview of recent progresses in drug discovery targeting PPIs through peptides or peptidomimetics, and will shed light on future therapeutic agent development toward the historically “intractable” PPI systems.
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影响因子：
--
作者：
de la Fuente-Núñez C;Reffuveille F;Mansour SC;Reckseidler-Zenteno SL;Hernández D;Brackman G;Coenye T;Hancock RE
通讯作者：
Hancock RE
设计蛋白质 - 蛋白质相互作用的螺旋肽抑制剂。
影响因子：
6.8
作者：
Rezaei Araghi R;Keating AE
通讯作者：
Keating AE
MDM2/X 靶向治疗的临床概述。
影响因子：
4.7
作者：
Burgess A;Chia KM;Haupt S;Thomas D;Haupt Y;Lim E
通讯作者：
Lim E
影响因子：
4
作者：
Rezaei Araghi R;Ryan JA;Letai A;Keating AE
通讯作者：
Keating AE
影响因子：
12.4
作者：
Adams JM;Cory S
通讯作者：
Cory S